The ménage à trois of autophagy, lipid droplets and liver disease.
Chaperone-mediated autophagy
fibrosis
hepatocellular carcinoma
macroautophagy
macrolipophagy
microautophagy
microlipophagy
nafld
nash
nonalcoholic fatty liver disease
nonalcoholic steatohepatitis
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
pubmed:
3
4
2021
medline:
29
4
2022
entrez:
2
4
2021
Statut:
ppublish
Résumé
Autophagic pathways cross with lipid homeostasis and thus provide energy and essential building blocks that are indispensable for liver functions. Energy deficiencies are compensated by breaking down lipid droplets (LDs), intracellular organelles that store neutral lipids, in part by a selective type of autophagy, referred to as lipophagy. The process of lipophagy does not appear to be properly regulated in fatty liver diseases (FLDs), an important risk factor for the development of hepatocellular carcinomas (HCC). Here we provide an overview on our current knowledge of the biogenesis and functions of LDs, and the mechanisms underlying their lysosomal turnover by autophagic processes. This review also focuses on nonalcoholic steatohepatitis (NASH), a specific type of FLD characterized by steatosis, chronic inflammation and cell death. Particular attention is paid to the role of macroautophagy and macrolipophagy in relation to the parenchymal and non-parenchymal cells of the liver in NASH, as this disease has been associated with inappropriate lipophagy in various cell types of the liver.
Identifiants
pubmed: 33794741
doi: 10.1080/15548627.2021.1895658
pmc: PMC8865253
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
50-72Références
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