Resistance to viral nervous necrosis in European sea bass (Dicentrarchus labrax L.): heritability and relationships with body weight, cortisol concentration, and antibody titer.
Journal
Genetics, selection, evolution : GSE
ISSN: 1297-9686
Titre abrégé: Genet Sel Evol
Pays: France
ID NLM: 9114088
Informations de publication
Date de publication:
01 Apr 2021
01 Apr 2021
Historique:
received:
09
11
2020
accepted:
23
03
2021
entrez:
2
4
2021
pubmed:
3
4
2021
medline:
20
7
2021
Statut:
epublish
Résumé
Susceptibility of European sea bass (Dicentrarchus labrax L.) to viral nervous necrosis (VNN) is well-known. Interest towards selective breeding as a tool to enhance genetic resistance in this species has increased sharply due to the major threat represented by VNN for farmed sea bass and limitations concerning specific therapeutical measures. A sea bass experimental population (N = 650) was challenged with nervous necrosis virus (NNV) to investigate genetic variation in VNN mortality. In addition, relationships of this trait with serum cortisol concentration after stress exposure, antibody titer against NNV antigens, and body weight at a fixed age were studied to identify potential indicator traits of VNN resistance. The estimate of heritability for VNN mortality was moderate and ranged from 0.15 (HPD95%, 95% highest posterior density interval: 0.02, 0.31) to 0.23 (HPD95%: 0.06, 0.47). Heritability estimates for cortisol concentration, antibody titer, and body weight were 0.19 (HPD95%: 0.07, 0.34), 0.36 (HPD95%: 0.16, 0.59) and 0.57 (HPD95%: 0.33, 0.84), respectively. Phenotypic relationships between traits were trivial and not statistically significant, except for the estimated correlation between antibody titer and body weight (0.24). Genetic correlations of mortality with body weight or antibody titer (- 0.39) exhibited a 0.89 probability of being negative. A negligible genetic correlation between mortality and cortisol concentration was detected. Antibody titer was estimated to be positively correlated with body weight (0.49). Antibody titer against NNV offers the opportunity to use indirect selection to enhance resistance, while the use of cortisol concentration as an indicator trait in breeding programs for VNN resistance is questionable. The estimate of heritability for VNN mortality indicates the feasibility of selective breeding to enhance resistance to NNV and raises attention to the development of genomic prediction tools to simplify testing procedures for selection candidates.
Sections du résumé
BACKGROUND
BACKGROUND
Susceptibility of European sea bass (Dicentrarchus labrax L.) to viral nervous necrosis (VNN) is well-known. Interest towards selective breeding as a tool to enhance genetic resistance in this species has increased sharply due to the major threat represented by VNN for farmed sea bass and limitations concerning specific therapeutical measures. A sea bass experimental population (N = 650) was challenged with nervous necrosis virus (NNV) to investigate genetic variation in VNN mortality. In addition, relationships of this trait with serum cortisol concentration after stress exposure, antibody titer against NNV antigens, and body weight at a fixed age were studied to identify potential indicator traits of VNN resistance.
RESULTS
RESULTS
The estimate of heritability for VNN mortality was moderate and ranged from 0.15 (HPD95%, 95% highest posterior density interval: 0.02, 0.31) to 0.23 (HPD95%: 0.06, 0.47). Heritability estimates for cortisol concentration, antibody titer, and body weight were 0.19 (HPD95%: 0.07, 0.34), 0.36 (HPD95%: 0.16, 0.59) and 0.57 (HPD95%: 0.33, 0.84), respectively. Phenotypic relationships between traits were trivial and not statistically significant, except for the estimated correlation between antibody titer and body weight (0.24). Genetic correlations of mortality with body weight or antibody titer (- 0.39) exhibited a 0.89 probability of being negative. A negligible genetic correlation between mortality and cortisol concentration was detected. Antibody titer was estimated to be positively correlated with body weight (0.49).
CONCLUSIONS
CONCLUSIONS
Antibody titer against NNV offers the opportunity to use indirect selection to enhance resistance, while the use of cortisol concentration as an indicator trait in breeding programs for VNN resistance is questionable. The estimate of heritability for VNN mortality indicates the feasibility of selective breeding to enhance resistance to NNV and raises attention to the development of genomic prediction tools to simplify testing procedures for selection candidates.
Identifiants
pubmed: 33794770
doi: 10.1186/s12711-021-00625-2
pii: 10.1186/s12711-021-00625-2
pmc: PMC8017662
doi:
Substances chimiques
Antibodies, Viral
0
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
32Références
J Fish Dis. 2014 Apr;37(4):371-83
pubmed: 23662921
Vet Res. 2016 Sep 02;47(1):89
pubmed: 27590537
Genet Sel Evol. 2012 Jun 19;44:15
pubmed: 22520515
J Biosci. 2007 Dec;32(7):1331-44
pubmed: 18202458
Fish Shellfish Immunol. 2003 May;14(5):435-47
pubmed: 12711276
Fish Shellfish Immunol. 2016 Jun;53:35-49
pubmed: 26997200
Nat Commun. 2014 Dec 23;5:5770
pubmed: 25534655
Fish Shellfish Immunol. 2006 Feb;20(2):137-51
pubmed: 15950491
Dev Comp Immunol. 2011 Dec;35(12):1256-62
pubmed: 21414351
J Anim Sci. 2013 Aug;91(8):3574-82
pubmed: 23736060
Virology. 1992 Mar;187(1):368-71
pubmed: 1736540
Genet Sel Evol. 2018 Jun 8;50(1):30
pubmed: 29884113
Mar Biotechnol (NY). 2014 Jun;16(3):349-60
pubmed: 24241385
Mol Ecol. 2013 Jun;22(11):3124-40
pubmed: 23701397
Rev Aquac. 2018 Aug;10(3):670-682
pubmed: 30220910
J Fish Dis. 2016 Jul;39(7):821-31
pubmed: 26610431
Nat Methods. 2012 May 20;9(8):808-10
pubmed: 22609625
Mol Ecol Resour. 2017 Sep;17(5):1009-1024
pubmed: 28271620
Dev Comp Immunol. 2014 Apr;43(2):174-83
pubmed: 23916690
Dev Comp Immunol. 2016 Dec;65:64-72
pubmed: 27370973
Vet Res. 1995;26(5-6):361-8
pubmed: 8581007
Dev Comp Immunol. 2004 Jan;28(1):39-49
pubmed: 12962981
J Fish Dis. 2017 May;40(5):717-742
pubmed: 27633881
Fish Shellfish Immunol. 2019 Feb;85:78-84
pubmed: 29175472
Mol Ecol. 2007 Mar;16(5):1099-106
pubmed: 17305863
Fish Shellfish Immunol. 2010 Feb;28(2):303-11
pubmed: 19925869
Fish Shellfish Immunol. 2019 May;88:458-463
pubmed: 30877059
Vet Immunol Immunopathol. 1994 Dec;44(1):85-95
pubmed: 7725631
BMC Genomics. 2014 Jun 17;15:478
pubmed: 24935670
Dis Aquat Organ. 2000 Nov 14;43(2):81-9
pubmed: 11145456
Mol Ecol. 1998 May;7(5):639-55
pubmed: 9633105
J Virol. 2006 Oct;80(20):10201-7
pubmed: 17005697
Poult Sci. 2015 Jul;94(7):1493-8
pubmed: 25910906