Cohort profile: Understanding Pregnancy Signals and Infant Development (UPSIDE): a pregnancy cohort study on prenatal exposure mechanisms for child health.
epidemiology
obstetrics
paediatrics
public health
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
entrez:
2
4
2021
pubmed:
3
4
2021
medline:
21
5
2021
Statut:
epublish
Résumé
Extensive research suggests that maternal prenatal distress is reliably related to perinatal and child health outcomes-which may persist into adulthood. However, basic questions remain regarding mechanisms involved. To better understand these mechanisms, we developed the Understanding Pregnancy Signals and Infant Development (UPSIDE) cohort study, which has several distinguishing features, including repeated assessments across trimesters, analysis of multiple biological pathways of interest, and incorporation of placental structure and function as mediators of child health outcomes. Women with normal risk pregnancies were recruited at <14 weeks gestation. Study visits occurred in each trimester and included extensive psychological, sociodemographic, health behaviour and biospecimen collection. Placenta and cord blood were collected at birth. Child visits (ongoing) occur at birth and 1, 6, 12, 24, 36 and 48 months of age and use standard anthropometric, clinical, behavioural, biological and neuroimaging methods to assess child physical and neurodevelopment. We recruited 326 pregnancies; 294 (90%) were retained through birth. Success rates for prenatal biospecimen collection were high across all trimesters (96%-99% for blood, 94%-97% for urine, 96%-99% for saliva, 96% of placentas, 88% for cord blood and 93% for buccal swab). Ninety-four per cent of eligible babies (n=277) participated in a birth examination; postnatal visits are ongoing. The current phase of the study follows children through age 4 to examine child neurodevelopment and physical development. In addition, the cohort participates in the National Institutes of Health's Environmental influences on Child Health Outcomes programme, a national study of 50 000 families examining early environmental influences on perinatal outcomes, neurodevelopment, obesity and airway disease. Future research will leverage the rich repository of biological samples and clinical data to expand research on the mechanisms of child health outcomes in relation to environmental chemical exposures, genetics and the microbiome.
Identifiants
pubmed: 33795306
pii: bmjopen-2020-044798
doi: 10.1136/bmjopen-2020-044798
pmc: PMC8021752
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e044798Subventions
Organisme : NIH HHS
ID : UH3 OD023349
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD083369
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029275
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES001247
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023349
Pays : United States
Organisme : NINR NIH HHS
ID : K23 NR019014
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES005022
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR000096
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029336
Pays : United States
Investigateurs
Jennifer Adibi
(J)
Lauren Aleksunes
(L)
Mary Caserta
(M)
Susan Groth
(S)
Philip Katzman
(P)
Eva Pressman
(E)
Xing Qiu
(X)
Zorimar Rivera-Nunez
(Z)
Kristin Scheible
(K)
Ruchit Shah
(R)
Loralei Thornburg
(L)
Sally Thurston
(S)
Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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