A decrease in NAD
Journal
NPJ aging and mechanisms of disease
ISSN: 2056-3973
Titre abrégé: NPJ Aging Mech Dis
Pays: England
ID NLM: 101678947
Informations de publication
Date de publication:
01 Apr 2021
01 Apr 2021
Historique:
received:
07
02
2020
accepted:
26
01
2021
entrez:
2
4
2021
pubmed:
3
4
2021
medline:
3
4
2021
Statut:
epublish
Résumé
Age-related osteoporosis is caused by a deficit in osteoblasts, the cells that secrete bone matrix. The number of osteoblast progenitors also declines with age associated with increased markers of cell senescence. The forkhead box O (FoxO) transcription factors attenuate Wnt/β-catenin signaling and the proliferation of osteoprogenitors, thereby decreasing bone formation. The NAD
Identifiants
pubmed: 33795658
doi: 10.1038/s41514-021-00058-7
pii: 10.1038/s41514-021-00058-7
pmc: PMC8016898
doi:
Types de publication
Journal Article
Langues
eng
Pagination
8Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM125503
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR056679
Pays : United States
Organisme : University of Arkansas for Medical Sciences (UAMS)
ID : UAMS Bone and Joint Initiative
Organisme : University of Arkansas for Medical Sciences (UAMS)
ID : Bone and Joint Initiative
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R01 AR56679
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
ID : R01 AR56679
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