Monocyte progenitors give rise to multinucleated giant cells.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
received:
20
08
2018
accepted:
23
02
2021
entrez:
2
4
2021
pubmed:
3
4
2021
medline:
20
4
2021
Statut:
epublish
Résumé
The immune response to mycobacteria is characterized by granuloma formation, which features multinucleated giant cells as a unique macrophage type. We previously found that multinucleated giant cells result from Toll-like receptor-induced DNA damage and cell autonomous cell cycle modifications. However, the giant cell progenitor identity remained unclear. Here, we show that the giant cell-forming potential is a particular trait of monocyte progenitors. Common monocyte progenitors potently produce cytokines in response to mycobacteria and their immune-active molecules. In addition, common monocyte progenitors accumulate cholesterol and lipids, which are prerequisites for giant cell transformation. Inducible monocyte progenitors are so far undescribed circulating common monocyte progenitor descendants with high giant cell-forming potential. Monocyte progenitors are induced in mycobacterial infections and localize to granulomas. Accordingly, they exhibit important immunological functions in mycobacterial infections. Moreover, their signature trait of high cholesterol metabolism may be piggy-backed by mycobacteria to create a permissive niche.
Identifiants
pubmed: 33795674
doi: 10.1038/s41467-021-22103-5
pii: 10.1038/s41467-021-22103-5
pmc: PMC8016882
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2027Références
Cell. 2014 Dec 18;159(7):1497-509
pubmed: 25525872
Biostatistics. 2003 Apr;4(2):249-64
pubmed: 12925520
Annu Rev Immunol. 2018 Apr 26;36:639-665
pubmed: 29400999
Nat Immunol. 2017 Feb 15;18(3):252-253
pubmed: 28198828
J Immunol. 2015 Sep 1;195(5):2383-95
pubmed: 26232427
J Lipid Res. 2012 Jul;53(7):1399-409
pubmed: 22517925
PLoS Pathog. 2015 Feb 12;11(2):e1004679
pubmed: 25675247
Immunol Lett. 2003 Jan 22;85(2):85-95
pubmed: 12527213
EMBO Rep. 2017 Dec;18(12):2144-2159
pubmed: 29097394
Infect Immun. 2004 May;72(5):2477-83
pubmed: 15102754
Immunity. 2014 Mar 20;40(3):315-27
pubmed: 24656045
Appl Environ Microbiol. 2001 Mar;67(3):1225-31
pubmed: 11229914
Can J Biochem Physiol. 1959 Aug;37(8):911-7
pubmed: 13671378
Microbiol Spectr. 2016 Oct;4(5):
pubmed: 27763255
Cell. 2020 Oct 29;183(3):752-770.e22
pubmed: 33125891
J Exp Med. 2015 Mar 9;212(3):385-99
pubmed: 25687283
Cell Rep. 2015 Dec 1;13(9):1937-48
pubmed: 26628365
Cell. 2012 Sep 28;151(1):138-52
pubmed: 23021221
Elife. 2015 Jun 26;4:e07999
pubmed: 26114596
Nat Commun. 2014 Sep 19;5:4978
pubmed: 25236377
Science. 2000 Jun 2;288(5471):1647-50
pubmed: 10834844
Semin Immunol. 2008 Apr;20(2):86-100
pubmed: 18162407
J Immunol. 2015 Mar 15;194(6):2735-45
pubmed: 25681348
Cell Rep. 2017 Jun 27;19(13):2743-2755
pubmed: 28658622
Cancer Res. 2004 Mar 15;64(6):2070-5
pubmed: 15026345
Nat Immunol. 2013 Aug;14(8):821-30
pubmed: 23812096
J Biol Chem. 2002 Sep 13;277(37):34573-80
pubmed: 12118008
J Intern Med. 2014 May;275(5):467-80
pubmed: 24635488
Cytometry A. 2011 Feb;79(2):95-101
pubmed: 21265003
J Bacteriol. 2009 Nov;191(21):6584-91
pubmed: 19717592
Cell Res. 2015 Dec;25(12):1333-51
pubmed: 26482950
Science. 2006 Jan 6;311(5757):83-7
pubmed: 16322423
J Exp Med. 2016 Oct 17;213(11):2293-2314
pubmed: 27811056
PLoS Pathog. 2009 Mar;5(3):e1000344
pubmed: 19300498
Immunity. 2017 May 16;46(5):835-848.e4
pubmed: 28514689
J Biol Chem. 2017 Jul 28;292(30):12436-12448
pubmed: 28615446
Front Immunol. 2013 Apr 22;4:98
pubmed: 23626591
Cell. 2019 Sep 5;178(6):1509-1525.e19
pubmed: 31491389
J Clin Invest. 2010 May;120(5):1674-82
pubmed: 20389020
J Pathol. 2007 Jan;211(1):76-85
pubmed: 17115379
Elife. 2013 Nov 12;2:e01086
pubmed: 24220507
J Steroid Biochem Mol Biol. 2017 May;169:152-163
pubmed: 27155346
Nat Protoc. 2006;1(3):1458-61
pubmed: 17406435
Diabetes. 2002 Jan;51(1):7-18
pubmed: 11756317
J Pathol. 2014 Nov;234(3):338-50
pubmed: 24979482
J Exp Med. 2009 Mar 16;206(3):595-606
pubmed: 19273628
Cell. 2018 Jan 11;172(1-2):176-190.e19
pubmed: 29328912
Cell. 2016 Nov 17;167(5):1264-1280.e18
pubmed: 28084216
Eur J Immunol. 2014 Aug;44(8):2380-93
pubmed: 24782112
PLoS One. 2017 Jan 3;12(1):e0169119
pubmed: 28046053
J Immunol. 2001 Apr 1;166(7):4697-704
pubmed: 11254730
Appl Environ Microbiol. 2010 Nov;76(21):7367-70
pubmed: 20817803
Arthritis Rheum. 2010 Feb;62(2):340-50
pubmed: 20112395
J Biol Chem. 1995 Jul 21;270(29):17250-6
pubmed: 7615524
Cell Microbiol. 2007 Dec;9(12):2768-74
pubmed: 17714517
J Clin Invest. 1997 Nov 15;100(10):2552-61
pubmed: 9366570
Nat Rev Immunol. 2008 Apr;8(4):290-301
pubmed: 18323850
J Infect Dis. 2014 Mar 1;209(5):754-63
pubmed: 24133190
Immunity. 2017 Nov 21;47(5):890-902.e4
pubmed: 29166589
Cureus. 2020 Mar 25;12(3):e7404
pubmed: 32337130
Cell Host Microbe. 2010 Jul 22;8(1):68-76
pubmed: 20638643
Nucleic Acids Res. 2019 Jan 8;47(D1):D419-D426
pubmed: 30407594
Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4376-80
pubmed: 18334639
Nat Immunol. 2013 Sep;14(9):893-900
pubmed: 23959186
Am J Pathol. 1925 Jan;1(1):91-100.1
pubmed: 19969635
Biochem Pharmacol. 2013 Jul 1;86(1):56-66
pubmed: 23583456
J Immunol. 2012 Sep 1;189(5):2151-8
pubmed: 22826320
Antimicrob Agents Chemother. 2014 Oct;58(10):5766-74
pubmed: 25049257
Curr Opin Microbiol. 2016 Feb;29:30-6
pubmed: 26544033
J Exp Med. 1998 Jul 20;188(2):399-404
pubmed: 9670052
Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7958-63
pubmed: 11438742
Cell Immunol. 1998 Sep 15;188(2):89-96
pubmed: 9756638
Sci Rep. 2017 Sep 21;7(1):12094
pubmed: 28935874