Paraneoplastic neurological syndromes: clinical presentations and management.
Paraneoplastic neurological syndrome
immune checkpoint inhibitor
onconeural antibodies
paraneoplastic neurological disorder
Journal
Therapeutic advances in neurological disorders
ISSN: 1756-2856
Titre abrégé: Ther Adv Neurol Disord
Pays: England
ID NLM: 101480242
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
03
2020
accepted:
11
12
2020
entrez:
2
4
2021
pubmed:
3
4
2021
medline:
3
4
2021
Statut:
epublish
Résumé
We provide an overview of the varied presentations of paraneoplastic neurological syndromes. We also review the onconeural antibodies and their particular oncological and neurological associations. Recognition of these syndromes and their oncological associations is crucial, as early diagnosis and management has been associated with better patient outcomes. Specific management strategies and prognosis vary widely depending on the underlying etiology. An understanding of the relevant clinical details, imaging findings, and other diagnostic information can help tailor treatment approaches. We provide an outline of the diagnostic evaluation and treatment of various paraneoplastic neurological disorders, presenting with central and/or peripheral nervous system involvement. We briefly discuss neurologic immune checkpoint inhibitor-related adverse events, which can occasionally present with paraneoplastic neurological syndrome phenotypes.
Identifiants
pubmed: 33796141
doi: 10.1177/1756286420985323
pii: 10.1177_1756286420985323
pmc: PMC7970694
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1756286420985323Informations de copyright
© The Author(s), 2021.
Déclaration de conflit d'intérêts
Conflict of interest statement: MFD, NK and EM report no disclosures. Divyanshu Dubey has a patent pending for Kelch-like protein 11 as a marker of neurological autoimmunity. Dr. Dubey has consulted for UCB and Astellas. All compensation for consulting activities is paid directly to Mayo Clinic.
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