Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer.
TLS
b cells
immunotherapy
neoantigens
pancreatic cancer
t cells
Journal
Oncoimmunology
ISSN: 2162-402X
Titre abrégé: Oncoimmunology
Pays: United States
ID NLM: 101570526
Informations de publication
Date de publication:
17 03 2021
17 03 2021
Historique:
entrez:
2
4
2021
pubmed:
3
4
2021
medline:
3
8
2021
Statut:
epublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) has traditionally been thought of as an immunologically quiescent tumor type presumably because of a relatively low tumor mutational burden (TMB) and poor responses to checkpoint blockade therapy. However, many PDAC tumors exhibit T cell inflamed phenotypes. The presence of tertiary lymphoid structures (TLS) has recently been shown to be predictive of checkpoint blockade response in melanomas and sarcomas, and are prognostic for survival in PDAC. In order to more comprehensively understand tumor immunity in PDAC patients with TLS, we performed RNA-seq, single and multiplex IHC, flow cytometry and predictive genomic analysis on treatment naïve, PDAC surgical specimens. Forty-six percent of tumors contained distinct T and B cell aggregates reflective of "early-stage TLS" (ES-TLS), which correlated with longer overall and progression-free survival. These tumors had greater CD8
Identifiants
pubmed: 33796412
doi: 10.1080/2162402X.2021.1900635
pii: 1900635
pmc: PMC7993148
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1900635Subventions
Organisme : NCI NIH HHS
ID : R01 CA182311
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA208644
Pays : United States
Informations de copyright
© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.
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