Case Report: Two Cases of Metastatic Pancreatoblastoma in Adults: Efficacy of Folfirinox and Implication of the Wnt/β-Catenin Pathway in Genomic Analysis.
Wnt/β-catenin
adult
chemotherapy—oncology
genomics
pancreatoblastoma
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
29
05
2020
accepted:
16
02
2021
entrez:
2
4
2021
pubmed:
3
4
2021
medline:
3
4
2021
Statut:
epublish
Résumé
Pancreatoblastomas are unfrequent tumors usually found in children. We report two cases of metastatic pancreatoblastomas observed in young women. A systemic chemotherapy (FOLFIRINOX regimen) was associated with a disease control in one case and a partial response in the second with an improvement of general status for both. A high-throughput sequencing of the tumor described in both cases alteration in the Wnt/β-catenin pathway: a mutation in
Identifiants
pubmed: 33796447
doi: 10.3389/fonc.2021.564506
pmc: PMC8007973
doi:
Types de publication
Case Reports
Langues
eng
Pagination
564506Informations de copyright
Copyright © 2021 Raoul, Oziel-Taieb, Lecomte, Adelaide, Guille, Chaffanet, Poizat, Heymann, Barbier and Bertucci.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absenceof any commercial or financial relationships that could be construed as a potential conflict of interest.
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