Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy.
Journal
Nature aging
ISSN: 2662-8465
Titre abrégé: Nat Aging
Pays: United States
ID NLM: 101773306
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
entrez:
2
4
2021
pubmed:
3
4
2021
medline:
3
4
2021
Statut:
ppublish
Résumé
Some humans age faster than others. Variation in biological aging can be measured in midlife, but the implications of this variation are poorly understood. We tested associations between midlife biological aging and indicators of future frailty-risk in the Dunedin cohort of 1037 infants born the same year and followed to age 45. Participants' Pace of Aging was quantified by tracking declining function in 19 biomarkers indexing the cardiovascular, metabolic, renal, immune, dental, and pulmonary systems across ages 26, 32, 38, and 45 years. At age 45 in 2019, participants with faster Pace of Aging had more cognitive difficulties, signs of advanced brain aging, diminished sensory-motor functions, older appearance, and more pessimistic perceptions of aging. People who are aging more rapidly than same-age peers in midlife may prematurely need supports to sustain independence that are usually reserved for older adults. Chronological age does not adequately identify need for such supports.
Identifiants
pubmed: 33796868
doi: 10.1038/s43587-021-00044-4
pmc: PMC8009092
mid: NIHMS1672843
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Pagination
295-308Subventions
Organisme : NICHD NIH HHS
ID : R03 HD050374
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG049789
Pays : United States
Organisme : Medical Research Council
ID : MR/P005918/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P30 AG034424
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG028716
Pays : United States
Organisme : NIA NIH HHS
ID : F99 AG068432
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG032282
Pays : United States
Commentaires et corrections
Type : CommentIn
Déclaration de conflit d'intérêts
Competing Interests The authors declare no competing interests.
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