Clinically applicable CD34
CD34+ hematopoietic progenitor cells
Clinical application
Dendritic cells
NK cells
T cells
Vaccination
Journal
Cancer immunology, immunotherapy : CII
ISSN: 1432-0851
Titre abrégé: Cancer Immunol Immunother
Pays: Germany
ID NLM: 8605732
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
20
10
2020
accepted:
22
02
2021
pubmed:
3
4
2021
medline:
16
10
2021
entrez:
2
4
2021
Statut:
ppublish
Résumé
Allogeneic stem cell transplantation (alloSCT), following induction chemotherapy, can be curative for hemato-oncology patients due to powerful graft-versus-tumor immunity. However, disease recurrence remains the major cause of treatment failure, emphasizing the need for potent adjuvant immunotherapy. In this regard, dendritic cell (DC) vaccination is highly attractive, as DCs are the key orchestrators of innate and adaptive immunity. Natural DC subsets are postulated to be more powerful compared with monocyte-derived DCs, due to their unique functional properties and cross-talk capacity. Yet, obtaining sufficient numbers of natural DCs, particularly type 1 conventional DCs (cDC1s), is challenging due to low frequencies in human blood. We developed a clinically applicable culture protocol using donor-derived G-CSF mobilized CD34
Identifiants
pubmed: 33796917
doi: 10.1007/s00262-021-02899-3
pii: 10.1007/s00262-021-02899-3
pmc: PMC8505305
doi:
Substances chimiques
Antigens, CD34
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3167-3181Subventions
Organisme : KWF Kankerbestrijding
ID : 10351
Organisme : KWF Kankerbestrijding
ID : 11079
Organisme : Health-Holland Foundation
ID : LSHM18048
Informations de copyright
© 2021. The Author(s).
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