Harnessing CRISPR-Cas system diversity for gene editing technologies.
CRISPR-Cas systems
DNA repair
DNA transposable elements
biological evolution
classification
gene editing
Journal
Journal of biomedical research
ISSN: 1674-8301
Titre abrégé: J Biomed Res
Pays: China
ID NLM: 101551157
Informations de publication
Date de publication:
26 Mar 2021
26 Mar 2021
Historique:
entrez:
2
4
2021
pubmed:
3
4
2021
medline:
3
4
2021
Statut:
ppublish
Résumé
The discovery and utilization of RNA-guided surveillance complexes, such as CRISPR-Cas9, for sequence-specific DNA or RNA cleavage, has revolutionised the process of gene modification or knockdown. To optimise the use of this technology, an exploratory race has ensued to discover or develop new RNA-guided endonucleases with the most flexible sequence targeting requirements, coupled with high cleavage efficacy and specificity. Here we review the constraints of existing gene editing and assess the merits of exploiting the diversity of CRISPR-Cas effectors as a methodology for surmounting these limitations.
Identifiants
pubmed: 33797415
doi: 10.7555/JBR.35.20200184
pmc: PMC8038530
doi:
Types de publication
Journal Article
Langues
eng
Pagination
91-106Références
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