Restoration of portal flow with varix in liver transplantation for patients with total portal vein thrombosis: An effective strategy in the largest center experience.

coronary-portal anastomosis gastric varix liver transplantation portal hypertension portal reconstruction portal vein thrombosis

Journal

Clinical transplantation
ISSN: 1399-0012
Titre abrégé: Clin Transplant
Pays: Denmark
ID NLM: 8710240

Informations de publication

Date de publication:
06 2021
Historique:
revised: 19 03 2021
received: 15 09 2020
accepted: 26 03 2021
pubmed: 3 4 2021
medline: 29 6 2021
entrez: 2 4 2021
Statut: ppublish

Résumé

Postoperative complications and worse prognosis still burden liver transplantations (LT) with complex portal vein thrombosis (CPVT). When an engorged left gastric vein (LGV) is present, the portal inflow is restorable with an anastomosis between the graft portal vein and the LGV of the recipient. We analyzed short- and long-term results of this procedure in 12 LT with CPVT. Between 2005 and 2019, 55 patients with CPVT underwent LT. We applied this technique in 12 patients. In six cases, we placed a vascular graft to obtain a tension-free structure. We evaluated patency, short- and long-term results. No intraoperative complication was observed. The median duration of LT, blood transfusion, deceased donor age, and MELD score of the recipients were 7 h, 1250 mL, 72 years, and 19. Seven patients were affected by hepatocellular carcinoma. No major complications or PVT recurrence were observed. One patient required a liver re-transplantation for primary non-functioning syndrome. The mean hospital stay was 20 days. The actuarial patient survival was 85% with a mean FU of 4 years. The two late deaths were due to hepatocellular carcinoma recurrence and sepsis for cholangitis. This technique in presence of both CPVT and engorged LGV is feasible and safe for patients, with good short- and long-term results.

Identifiants

pubmed: 33797802
doi: 10.1111/ctr.14303
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e14303

Informations de copyright

© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Références

Van Thiel DH, Schade RR, Starzl TE, et al. Liver transplantation in adults. Hepatology. 1982;2:637S-640S.
Zanetto A, Rodriguez-Kastro K-I, Germani G, et al. Mortality in liver transplant recipients with portal vein thrombosis - an updated meta-analysis. Transpl Int. 2018;31:1318-1329.
Bhangui P, Lim C, Levesque E, et al. Novel classification of non-malignant portal vein thrombosis: a guide to surgical decision-making during liver transplantation. J Hepatol. 2019;71:1038-1050.
Yerdel MA, Gunson B, Mirza D, et al. Portal vein thrombosis in adults undergoing liver transplantation: Risk factors, screening, management, and outcome. Transplantation. 2000;69:1873-1881.
Jamieson NV. Changing perspectives in portal vein thrombosis and liver transplantation. Transplantation. 2000;69:1772-1774.
Charco R, Fuster J, Fondevila C, Ferrer J, Mans E, García-Valdecasas JC. Portal vein thrombosis in liver transplantation. Transplant Proc. 2005;37(9):3904-3905.
Lerut J, Tzakis AG, Bron K, et al. Complications of venous reconstruction in human orthotopic liver transplantation. Ann Surg. 1987;205:404-414.
Hibi T, Nishida S, Levi DM, et al. When and why portal vein thrombosis matters in liver transplantation: a critical audit of 174 cases. Ann Surg. 2014;259:760-766.
Czerniak A, Badger I, Sherlock D, Buckels J. Orthotopic liver transplantation in a patient with thrombosis of the hepatic portal and superior mesenteric veins. Transplantation. 1990;50:334-336.
Stieber AC, Zetti G, Todo S, et al. The spectrum of portal vein thrombosis in liver transplantation. Ann Surg. 1991;213:199-206.
Orlando G, De Luca L, Toti L, et al. Liver transplantation in the presence of portal vein thrombosis: report from a single center. Transplant Proc. 2004;36:199-202.
Maluf D, Shim I, Posner M, Cotterell AH, Fisher RA. Salvage procedure for unexpected portal vein thrombosis in living donor liver transplantation. Transplant Proc. 2006;38:1422-1424.
Lladó L, Fabregat J, Castellote J, et al. Management of portal vein thrombosis in liver transplantation: Influence on morbidity and mortality. Clin Transplant. 2007;21:716-721.
Pan C, Shi Y, Zhang JJ, et al. Single-center experience of 253 portal vein thrombosis patients undergoing liver transplantation in China. Transplant Proc. 2009;41:3761-3765.
Wu TH, Chou HS, Pan KT, et al. Application of cryopreserved vein grafts as a conduit between the coronary vein and liver graft to reconstruct portal flow in adult living liver transplantation. Clin Transplant. 2009;23:751-755.
Ramos AP, Reigada CPH, Ataíde EC, et al. Portal vein thrombosis and liver transplantation: long term. Transplant Proc. 2010;42:498-501.
Kim JD, Choi DL, Han YS. An early single-center experience of portal vein thrombosis in living donor liver transplantation: clinical feature, management and outcome. J Korean Surg Soc. 2011;81:35-42.
Ravaioli M, Zanello M, Grazi GL, et al. Portal vein thrombosis and liver transplantation: evolution during 10 years of experience at the university of bologna. Ann Surg. 2011;253:378-384.
Alexopoulos SP, Thomas E, Berry E, Whang G, Matsuoka L. The portal vein-variceal anastomosis: an important technique for establishing portal vein inflow. Clin Transplant. 2014;28:52-57.
Wang Z, Yang L. Gastric coronary vein to portal vein reconstruction in liver transplant: case report. Exp Clin Transplant. 2014;12:562-564.
Teixeira UF, Machry MC, Goldoni MB, et al. Use of left gastric vein as an alternative for portal flow reconstruction in liver transplantation. Case Rep Surg. 2016;2016:1-4.
Safwan M, Nagai S, Abouljoud MS. Portal vein inflow from enlarged coronary vein in liver transplantation: surgical approach and technical tips: a case report. Transplant Proc. 2016;48:3070-3072.
Gomez Gavara C, Bhangui P, Salloum C, et al. Ligation versus no ligation of spontaneous portosystemic shunts during liver transplantation: audit of a prospective series of 66 consecutive patients. Liver Transplant. 2018;24:505-515.
Golse N, Mohkam K, Rode A, et al. Surgical management of large spontaneous portosystemic splenorenal shunts during liver transplantation: splenectomy or left renal vein ligation? Transplant Proc. 2015;47:1866-1876.
Clavien PA, Barkun J, De Oliveira ML, et al. The clavien-dindo classification of surgical complications: Five-year experience. Ann Surg. 2009;250:187-196.
Vodkin I, Kuo A. Extended criteria donors in liver transplantation. Clin Liver Dis. 2017;21:289-301.
Kootstra G, Daemen JH, Oomen AP. Categories of non-heart-beating donors. Transplant Proc. 1995;27:2893-2894.
Idezuki Y. General rules for recording endoscopic findings of esophagogastric varices (1991). World J Surg. 1995;19(3):420-422.discussion 423.
Lauro A, Di Benedetto F, Masetti M, et al. Twenty-seven consecutive intestinal and multivisceral transplants in adult patients: a 4-year clinical experience. Transplant Proc. 2005;37:2679-2681.
Singh AK, Nachiappan AC, Verma HA, et al. Postoperative imaging in liver transplantation: what radiologists should know. Radiographics. 2010;30:339-351.
Bhangui P, Lim C, Salloum C, et al. Caval inflow to the graft for liver transplantation in patients with diffuse portal vein thrombosis: a 12-Year experience. Ann Surg. 2011;254:1008-1016.
Lodato F, Berzigotti A, Lisotti A, et al. Transjugular intrahepatic portosystemic shunt placement for refractory ascites: a single-centre experience. Scand J Gastroenterol. 2012;47:1494-1500.
Englesbe MJ. Portal vein thrombosis and liver transplant survival benefit. Liver Transplant. 2010;16:999-1005.
Ravaioli M, Grazi GL, Cescon M, et al. Liver transplantations with donors aged 60 years and above: the low liver damage strategy. Transpl Int. 2009;22:423-433.
Rizzari MD, Safwan M, Sobolic M, et al. The impact of portal vein thrombosis on liver transplant outcomes. Transplantation. 2020.
Ravaioli M, Grande G, Di Gioia P, et al. Risk avoidance and liver transplantation a single-center experience in a national network. Ann Surg. 2016;264:778-786.

Auteurs

Matteo Ravaioli (M)

Department of General Surgery and Transplantation, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Department of General Surgery and Transplantation, University of Bologna, Bologna, Italy.

Enrico Prosperi (E)

Department of General Surgery and Transplantation, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Antonio Pinna (A)

Department of General Surgery and Transplantation, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Antonio Siniscalchi (A)

Department of General Surgery and Transplantation, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Guido Fallani (G)

Department of General Surgery and Transplantation, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Giacomo Frascaroli (G)

Department of General Surgery and Transplantation, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Lorenzo Maroni (L)

Department of General Surgery and Transplantation, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Federica Odaldi (F)

Department of General Surgery and Transplantation, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Matteo Serenari (M)

Department of General Surgery and Transplantation, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Matteo Cescon (M)

Department of General Surgery and Transplantation, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Department of General Surgery and Transplantation, University of Bologna, Bologna, Italy.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH