Semiflexible Immunobrushes Induce Enhanced T Cell Activation and Expansion.
adoptive cell therapy
artificial antigen-presenting cell
immunotherapy
polyisocyanopeptide
polymer brush surface
Journal
ACS applied materials & interfaces
ISSN: 1944-8252
Titre abrégé: ACS Appl Mater Interfaces
Pays: United States
ID NLM: 101504991
Informations de publication
Date de publication:
14 Apr 2021
14 Apr 2021
Historique:
pubmed:
3
4
2021
medline:
11
8
2021
entrez:
2
4
2021
Statut:
ppublish
Résumé
A variety of bioactive materials developed to expand T cells for adoptive transfer into cancer patients are currently evaluated in the clinic. In most cases, T cell activating biomolecules are attached to rigid surfaces or matrices and form a static interface between materials and the signaling receptors on the T cells. We hypothesized that a T cell activating polymer brush interface might better mimic the cell surface of a natural antigen-presenting cell, facilitating receptor movement and concomitant advantageous mechanical forces to provide enhanced T cell activating capacities. Here, as a proof of concept, we synthesized semiflexible polyisocyanopeptide (PIC) polymer-based immunobrushes equipped with T cell activating agonistic anti-CD3 (αCD3) and αCD28 antibodies placed on magnetic microbeads. We demonstrated enhanced efficiency of
Identifiants
pubmed: 33797875
doi: 10.1021/acsami.0c21994
pmc: PMC8045021
doi:
Substances chimiques
Biocompatible Materials
0
Peptides
0
Polyurethanes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
16007-16018Références
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