JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging.

Aging / metabolism Animals Apoptosis Bile Duct Diseases / etiology Biopsy Caspase 8 / metabolism Cysts / etiology Disease Models, Animal Disease Susceptibility Immunohistochemistry Immunophenotyping Liver Diseases / etiology MAP Kinase Signaling System Mice Mitogen-Activated Protein Kinase 8 / deficiency Necroptosis Receptor-Interacting Protein Serine-Threonine Kinases / genetics
MK2 cholangiocytes liver liver cysts programmed cell death

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
23 03 2021
Historique:
entrez: 2 4 2021
pubmed: 3 4 2021
medline: 7 9 2021
Statut: ppublish

Résumé

The c-Jun N-terminal kinase (JNK) signaling pathway mediates adaptation to stress signals and has been associated with cell death, cell proliferation, and malignant transformation in the liver. However, up to now, its function was experimentally studied mainly in young mice. By generating mice with combined conditional ablation of

Identifiants

DOI: 10.1073/pnas.2007194118 PMID: 33798093 PMC: PMC8000530
pubmed: 33798093
pii: 2007194118
doi: 10.1073/pnas.2007194118
pmc: PMC8000530
pii:
doi:

Substances chimiques

RIPK1 protein, human EC 2.7.11.1
Receptor-Interacting Protein Serine-Threonine Kinases EC 2.7.11.1
Mitogen-Activated Protein Kinase 8 EC 2.7.11.24
Caspase 8 EC 3.4.22.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK107220
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK121545
Pays : United States

Informations de copyright

Copyright © 2021 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

The authors declare no competing interest.

Références

Gastroenterology. 2012 Aug;143(2):307-20
pubmed: 22705006
Hepatology. 2016 Jul;64(1):306-8
pubmed: 26389825
Oncotarget. 2015 Feb 20;6(5):2903-16
pubmed: 25609201
Transplant Proc. 2017 Apr;49(3):603-605
pubmed: 28340841
Nat Rev Gastroenterol Hepatol. 2014 Dec;11(12):750-61
pubmed: 25266109
Genesis. 2000 Feb;26(2):149-50
pubmed: 10686614
Genes Dev. 2003 Apr 1;17(7):883-95
pubmed: 12654726
Mol Cell. 2015 Oct 1;60(1):63-76
pubmed: 26344099
Proteomics Clin Appl. 2008 Jul 1;2(7-8):1140-1152
pubmed: 20411046
Cell Metab. 2014 Sep 2;20(3):512-25
pubmed: 25043817
Cancer Cell. 2017 Sep 11;32(3):342-359.e10
pubmed: 28898696
Sem Hop. 1958 Feb 18;34(8/2):488-95/SP
pubmed: 13543375
Science. 2013 Jan 11;339(6116):218-22
pubmed: 23223452
Cancer Cell. 2010 May 18;17(5):481-96
pubmed: 20478530
Oncotarget. 2016 Nov 29;8(32):52321-52332
pubmed: 28881732
Mol Cell Oncol. 2017 Mar 22;4(3):e1304191
pubmed: 28616581
J Proteome Res. 2008 Jun;7(6):2490-5
pubmed: 18419150
Nat Cell Biol. 2017 Oct;19(10):1237-1247
pubmed: 28920952
Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1491-1497
pubmed: 28782656
Cancers (Basel). 2019 Jul 17;11(7):
pubmed: 31319593
Neuron. 1999 Apr;22(4):667-76
pubmed: 10230788
Semin Immunol. 2014 Jun;26(3):237-45
pubmed: 24647229
EMBO Rep. 2008 Oct;9(10):1048-54
pubmed: 18704119
Immunity. 2013 Sep 19;39(3):443-53
pubmed: 24012422
Curr Protoc Mouse Biol. 2016 Jun 01;6(2):185-200
pubmed: 27248434
Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15759-64
pubmed: 17893331
Development. 2011 Feb;138(4):653-65
pubmed: 21266405
Onco Targets Ther. 2019 Nov 01;12:9029-9040
pubmed: 31806991
Hepatology. 2016 Oct;64(4):1217-31
pubmed: 27396433
Mol Cell. 2019 Feb 7;73(3):413-428.e7
pubmed: 30598363
J Cell Physiol. 2012 Mar;227(3):1157-67
pubmed: 21567405
Adv Cancer Res. 2009;104:139-70
pubmed: 19878776
Abdom Radiol (NY). 2019 Jun;44(6):2156-2171
pubmed: 30852632
Sem Hop. 1958 Feb 18;34(8/2):496-502/SP
pubmed: 13543376
Nat Rev Gastroenterol Hepatol. 2018 Dec;15(12):738-752
pubmed: 30250076
Cell Rep. 2013 Aug 29;4(4):776-90
pubmed: 23972991
Nat Cell Biol. 2017 Oct;19(10):1248-1259
pubmed: 28920954
Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16492-16499
pubmed: 32601222
Am J Physiol Renal Physiol. 2017 Dec 1;313(6):F1223-F1231
pubmed: 28877884
Clin J Gastroenterol. 2019 Apr;12(2):106-111
pubmed: 30343465
Genesis. 2000 Feb;26(2):151-3
pubmed: 10686615
Mech Dev. 1999 Dec;89(1-2):115-24
pubmed: 10559486
J Am Soc Nephrol. 2006 Jun;17(6):1604-14
pubmed: 16641154
J Biol Chem. 2010 Apr 2;285(14):10243-51
pubmed: 20106977
Genes Cancer. 2017 Sep;8(9-10):682-694
pubmed: 29234486
World J Gastroenterol. 2007 Apr 7;13(13):1934-7
pubmed: 17461493
Cancer Cell. 2017 Jan 9;31(1):94-109
pubmed: 28017612

Auteurs

Katrin Müller (K)

Division of Biliary and Gastrointestinal Oncology, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, 52074 Aachen, Germany.

Hanna Honcharova-Biletska (H)

Department of Pathology and Molecular Pathology, University of Zurich and University Hospital Zurich, 8091 Zurich, Switzerland.
ORCID: 0000-0002-9032-5137

Christiane Koppe (C)

Division of Biliary and Gastrointestinal Oncology, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, 52074 Aachen, Germany.

Michèle Egger (M)

Department of Pathology and Molecular Pathology, University of Zurich and University Hospital Zurich, 8091 Zurich, Switzerland.

Lap Kwan Chan (LK)

Department of Pathology and Molecular Pathology, University of Zurich and University Hospital Zurich, 8091 Zurich, Switzerland.
ORCID: 0000-0002-9165-6982

Anne T Schneider (AT)

Division of Biliary and Gastrointestinal Oncology, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, 52074 Aachen, Germany.

Lena Küsgens (L)

Division of Biliary and Gastrointestinal Oncology, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, 52074 Aachen, Germany.

Friederike Böhm (F)

Department of Pathology and Molecular Pathology, University of Zurich and University Hospital Zurich, 8091 Zurich, Switzerland.

Yannick Boege (Y)

Department of Pathology and Molecular Pathology, University of Zurich and University Hospital Zurich, 8091 Zurich, Switzerland.

Marc E Healy (ME)

Department of Pathology and Molecular Pathology, University of Zurich and University Hospital Zurich, 8091 Zurich, Switzerland.
ORCID: 0000-0001-9441-1166

Johannes Schmitt (J)

Department of Pathology and Molecular Pathology, University of Zurich and University Hospital Zurich, 8091 Zurich, Switzerland.
ORCID: 0000-0002-8099-8792

Sarah Comtesse (S)

Department of Pathology and Molecular Pathology, University of Zurich and University Hospital Zurich, 8091 Zurich, Switzerland.

Mirco Castoldi (M)

Division of Biliary and Gastrointestinal Oncology, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, 52074 Aachen, Germany.
Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty, Heinrich Heine University, 40225 Duesseldorf, Germany.

Christian Preisinger (C)

Proteomics Core Facility, Interdisciplinary Center for Clinical Research, University Hospital RWTH Aachen, 52074 Aachen, Germany.

Marta Szydlowska (M)

Division of Chronic Inflammation and Cancer, German Cancer Research Center (Deutsches Krebsforschungszentrum), 69120 Heidelberg, Germany.
ORCID: 0000-0002-4660-899X

Enrico Focaccia (E)

Division of Chronic Inflammation and Cancer, German Cancer Research Center (Deutsches Krebsforschungszentrum), 69120 Heidelberg, Germany.
ORCID: 0000-0001-9913-3492

Nadine T Gaisa (NT)

Institute of Pathology, University Hospital RWTH Aachen, 52074 Aachen, Germany.
ORCID: 0000-0002-4762-3964

Sven H Loosen (SH)

Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty, Heinrich Heine University, 40225 Duesseldorf, Germany.

Simone Jörs (S)

Internal Medicine II, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany.
ORCID: 0000-0002-5721-2878

Frank Tacke (F)

Department of Hepatology and Gastroenterology, Charité University Medical Center Berlin, 10117 Berlin, Germany.
ORCID: 0000-0001-6206-0226

Christoph Roderburg (C)

Department of Hepatology and Gastroenterology, Charité University Medical Center Berlin, 10117 Berlin, Germany.

Verena Keitel (V)

Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty, Heinrich Heine University, 40225 Duesseldorf, Germany.

Johannes G Bode (JG)

Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty, Heinrich Heine University, 40225 Duesseldorf, Germany.
ORCID: 0000-0002-7141-0694

Peter Boor (P)

Institute of Pathology, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Department of Nephrology and Immunology, University Hospital RWTH Aachen, 52074 Aachen, Germany.
ORCID: 0000-0001-9921-4284

Roger J Davis (RJ)

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605.
ORCID: 0000-0002-0130-1652

Thomas Longerich (T)

Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Fabian Geisler (F)

Internal Medicine II, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany.
ORCID: 0000-0003-1545-485X

Mathias Heikenwalder (M)

Division of Chronic Inflammation and Cancer, German Cancer Research Center (Deutsches Krebsforschungszentrum), 69120 Heidelberg, Germany.

Achim Weber (A)

Department of Pathology and Molecular Pathology, University of Zurich and University Hospital Zurich, 8091 Zurich, Switzerland; achim.weber@usz.ch luedde@hhu.de.
Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland.

Mihael Vucur (M)

Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty, Heinrich Heine University, 40225 Duesseldorf, Germany.

Tom Luedde (T)

Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty, Heinrich Heine University, 40225 Duesseldorf, Germany; achim.weber@usz.ch luedde@hhu.de.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › JNK signaling prevents biliary cyst formation...
questionsmedicales.fr › Eucaryotes › Animaux › JNK signaling prevents biliary cyst formation...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › JNK signaling prevents biliary cyst formation...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladie des voies biliaires › Maladies des canaux biliaires › JNK signaling prevents biliary cyst formation...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytodiagnostic › Biopsie › JNK signaling prevents biliary cyst formation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Protéines adaptatrices de signalisation des récepteurs à domaine de mort › Caspase 8 › JNK signaling prevents biliary cyst formation...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Kystes › JNK signaling prevents biliary cyst formation...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › JNK signaling prevents biliary cyst formation...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Prédisposition aux maladies › JNK signaling prevents biliary cyst formation...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Immunohistochimie › JNK signaling prevents biliary cyst formation...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Immunophénotypage › JNK signaling prevents biliary cyst formation...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › JNK signaling prevents biliary cyst formation...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Système de signalisation des MAP kinases › JNK signaling prevents biliary cyst formation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › JNK signaling prevents biliary cyst formation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › JNK Mitogen-Activated Protein Kinases › Mitogen-Activated Protein Kinase 8 › JNK signaling prevents biliary cyst formation...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Nécroptose › JNK signaling prevents biliary cyst formation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Receptor-Interacting Protein Serine-Threonine Kinases › JNK signaling prevents biliary cyst formation...