Higher airborne pollen concentrations correlated with increased SARS-CoV-2 infection rates, as evidenced from 31 countries across the globe.
COVID-19
aerobiology
pollen
viral infection
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
23 03 2021
23 03 2021
Historique:
entrez:
2
4
2021
pubmed:
3
4
2021
medline:
14
4
2021
Statut:
ppublish
Résumé
Pollen exposure weakens the immunity against certain seasonal respiratory viruses by diminishing the antiviral interferon response. Here we investigate whether the same applies to the pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is sensitive to antiviral interferons, if infection waves coincide with high airborne pollen concentrations. Our original hypothesis was that more airborne pollen would lead to increases in infection rates. To examine this, we performed a cross-sectional and longitudinal data analysis on SARS-CoV-2 infection, airborne pollen, and meteorological factors. Our dataset is the most comprehensive, largest possible worldwide from 130 stations, across 31 countries and five continents. To explicitly investigate the effects of social contact, we additionally considered population density of each study area, as well as lockdown effects, in all possible combinations: without any lockdown, with mixed lockdown-no lockdown regime, and under complete lockdown. We found that airborne pollen, sometimes in synergy with humidity and temperature, explained, on average, 44% of the infection rate variability. Infection rates increased after higher pollen concentrations most frequently during the four previous days. Without lockdown, an increase of pollen abundance by 100 pollen/m
Identifiants
pubmed: 33798095
pii: 2019034118
doi: 10.1073/pnas.2019034118
pmc: PMC7999946
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIEHS NIH HHS
ID : Y01 ES000001
Pays : United States
Investigateurs
Gilles Oliver
(G)
Nhan Pham-Thi
(N)
M Thibaudon
(M)
Arturo H Arino
(AH)
J Belmonte
(J)
Patricia Cervigon Morales
(PC)
Concepcion de Linares
(C)
Delia Fernández
(D)
Santiago Fernandez-Rodriguez
(S)
Antonia Gabaldon Arguisuelas
(AG)
Carmen Galan
(C)
Monica González-Alonso
(M)
Beatriz Lara
(B)
José María Moreno Grau
(JMM)
José Oteros
(J)
Rosa Pérez-Badia
(R)
Anabel Pérez-de-Zabalza
(A)
Antonio Picornell
(A)
Marta Recio
(M)
Estrella Robles
(E)
Alberto Rodríguez-Fernández
(A)
Javier F Rodríguez-Rajo
(JF)
Jesús Rojo
(J)
Luis Ruiz Valenzuela
(LR)
Karl-Christian Bergmann
(KC)
Barbora Werchan
(B)
Matthias Werchan
(M)
Jeroen T M Buters
(JTM)
Maximilian Bastl
(M)
Susanne Dunker
(S)
Thomas Hornick
(T)
Nestor González Roldán
(NG)
Stefan Gilge
(S)
B Clot
(B)
Stanley Finemann
(S)
Linda B Ford
(LB)
Robert Anthony Gomez
(RA)
Sanjay Kamboj
(S)
Wayne Wilhelm
(W)
Paul J Beggs
(PJ)
Pamela Burton
(P)
Janet M Davies
(JM)
Simon Haberle
(S)
Constance Helen Katelaris
(CH)
Ben Keaney
(B)
Andelija Milic
(A)
Victoria Miller
(V)
Shanice van Haeften
(S)
Maira Bonini
(M)
Anna Bordin
(A)
Valentina Ceriotti
(V)
Fabiana Cristofolini
(F)
Antonella Cristofori
(A)
Elena Gottardini
(E)
Guido Marcer
(G)
Paolo Marraccini
(P)
Paolo Mascagni
(P)
Antonio Meriggi
(A)
Loretta Pace
(L)
Alberto Pini
(A)
Maria Cristina Tacca
(MC)
Nicolas Bruffaerts
(N)
Lucie Hoebeke
(L)
Beverley Adams-Groom
(B)
Catherine Helen Pashley
(CH)
Jack Satchwell
(J)
C A Skjøth
(CA)
Fiona A Symon
(FA)
Celia Maria Miguel Antunes
(CM)
Elsa Caeiro
(E)
Irene Gomes Câmara Camacho
(IGC)
Ana Cristina Rodrigues Costa
(AC)
Ricardo João Ratola Capela Deus
(RJRC)
Manuel Branco Ferreira
(MB)
Joao Almeida Lopes Fonseca
(JA)
Ana Catarina Galveias Jorge
(AC)
Helena Ribeiro
(H)
Beatriz Tavares
(B)
Łukasz Grewling
(Ł)
Agnieszka Grinn-Gofroń
(A)
Dariusz Jurkiewicz
(D)
Ewa Kalinowska
(E)
Agnieszka A Lipiec
(AA)
Dorota Myszkowska
(D)
Krystyna Piotrowska-Weryszko
(K)
Malgorzata Puc
(M)
Anna Agnieszka Rapiejko
(AA)
Piotr Rapiejko
(P)
Elżbieta Weryszko-Chmielewska
(E)
Monika Ziemianin
(M)
Dilys Berman
(D)
Werner Hoek
(W)
Ahmed Ismail Manjra
(AI)
Jonathan Peter
(J)
Å Dahl
(Å)
Agneta Ekebom
(A)
Barbara Stjepanovic
(B)
Ana Večenaj
(A)
S Celenk
(S)
Ozlem Goksel
(O)
Tuncay Goksel
(T)
Aykut Guvensen
(A)
Nur Munevver Pinar
(NM)
Cansin Sackesen
(C)
Aydar Acar Sahin
(AA)
Ulas Uguz
(U)
Duygu Yazici
(D)
Dóra Kajitor-Apatini
(D)
Donát Magyar
(D)
Tamás Szigeti
(T)
Branko Sikoparija
(B)
Andreja Kofol Seliger
(AK)
Anja Simčič
(A)
Jae-Won Oh
(JW)
Athanasios Charalampopoulos
(A)
D Vokou
(D)
K Rasmussen
(K)
Laura Beatriz Barrionuevo
(LB)
German Dario Ramon
(GD)
Letty A de Weger
(LA)
Mieke M J F Koenders
(MMJF)
Arnold J H van Vliet
(AJH)
Jozef Dušička
(J)
Janka Lafférsová
(J)
Jana Ščevková
(J)
O Rybníček
(O)
Frances Coates
(F)
Dawn Jurgens
(D)
Ingrida Šaulienė
(I)
Elena Severova
(E)
V Rodinkova
(V)
Mykyta Bortnyk
(M)
Olena Palamarchuk
(O)
Maryna Yasniuk
(M)
Maria Louna-Korteniemi
(M)
Sanna Pätsi
(S)
Annika Saarto
(A)
Linnea Toiviainen
(L)
Olga Sozinova
(O)
Peng Jia
(P)
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
Références
J Allergy Clin Immunol. 2020 Sep;146(3):583-594.e6
pubmed: 32272131
Lancet Infect Dis. 2020 Jul;20(7):776-777
pubmed: 32224313
Cell Death Dis. 2012 Mar 08;3:e277
pubmed: 22402601
Sci Total Environ. 2021 Feb 25;757:143757
pubmed: 33272604
Emerg Microbes Infect. 2020 Dec;9(1):558-570
pubmed: 32172672
Front Public Health. 2020 Nov 26;8:580057
pubmed: 33324598
Allergy. 2020 Mar;75(3):576-587
pubmed: 31512243
J Allergy Clin Immunol. 2019 Dec;144(6):1551-1565.e2
pubmed: 31449915
PLoS One. 2015 Jan 15;10(1):e0113170
pubmed: 25590618
J Allergy Clin Immunol. 2019 Dec;144(6):1542-1550.e1
pubmed: 31536730
Immun Inflamm Dis. 2016 Apr 15;4(2):166-181
pubmed: 27957326
World Allergy Organ J. 2020 Mar 09;13(3):100109
pubmed: 32180893
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Int J Environ Res Public Health. 2020 Dec 11;17(24):
pubmed: 33322456
Trends Ecol Evol. 1996;11(1):33-7
pubmed: 21237757
Euro Surveill. 2020 Apr;25(17):
pubmed: 32372755
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
ACS Chem Neurosci. 2020 May 6;11(9):1200-1203
pubmed: 32283006
Infect Dis Model. 2020 Jan 08;5:129-141
pubmed: 31956741
Sci Rep. 2015 Dec 16;5:18178
pubmed: 26670777
Lancet Planet Health. 2019 Mar;3(3):e124-e131
pubmed: 30904111
World Allergy Organ J. 2015 Jan 20;8(1):2
pubmed: 25610519
J Immunol. 2009 Jun 1;182(11):6653-8
pubmed: 19454659
Clin Exp Allergy. 2016 Oct;46(10):1355-65
pubmed: 27061126
Mucosal Immunol. 2013 Jul;6(4):797-806
pubmed: 23212197
J Virol. 2014 Jan;88(2):913-24
pubmed: 24198408
J Allergy Clin Immunol Pract. 2020 Jun;8(6):1798-1801
pubmed: 32311489
Exp Dermatol. 2016 Dec;25(12):991-993
pubmed: 27306558
J Infect Dis. 2020 Jun 16;222(1):26-33
pubmed: 32339231
J Allergy Clin Immunol. 2018 May;141(5):1607-1619.e9
pubmed: 28947081
Annu Rev Virol. 2020 Sep 29;7(1):83-101
pubmed: 32196426
Int J Environ Res Public Health. 2020 Dec 13;17(24):
pubmed: 33322089
J Exp Med. 2020 May 4;217(5):
pubmed: 32289152
Virol Sin. 2016 Feb;31(1):12-23
pubmed: 26786772
FASEB J. 2019 Aug;33(8):8865-8877
pubmed: 31034780
Cell Death Discov. 2019 Jun 5;5:101
pubmed: 31231549
Sci Total Environ. 2021 Jan 10;751:141816
pubmed: 32861186
EMBO Mol Med. 2020 Jun 8;12(6):e12465
pubmed: 32333818
Nat Med. 2020 May;26(5):681-687
pubmed: 32327758
Clin Infect Dis. 2020 Sep 12;71(6):1410-1412
pubmed: 32301957
Pharmacol Res. 2020 Jul;157:104821
pubmed: 32360481
J Pathol. 2006 Nov;210(3):288-97
pubmed: 17031779
Sci Total Environ. 2021 Feb 10;755(Pt 1):142881
pubmed: 33097263