Adrenal medulla development and medullary-cortical interactions.
Adrenal
Cortex
Development
Interactions
Medulla
Pathologies
Stem cells
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
15 05 2021
15 05 2021
Historique:
received:
17
11
2020
revised:
12
03
2021
accepted:
22
03
2021
pubmed:
3
4
2021
medline:
1
12
2021
entrez:
2
4
2021
Statut:
ppublish
Résumé
The mammalian adrenal gland is composed of two distinct tissue types in a bidirectional connection, the catecholamine-producing medulla derived from the neural crest and the mesoderm-derived cortex producing steroids. The medulla mainly consists of chromaffin cells derived from multipotent nerve-associated descendants of Schwann cell precursors. Already during adrenal organogenesis, close interactions between cortex and medulla are necessary for proper differentiation and morphogenesis of the gland. Moreover, communication between the cortex and the medulla ensures a regular function of the adult adrenal. In tumor development, interfaces between the two parts are also common. Here, we summarize the development of the mammalian adrenal medulla and the current understanding of the cortical-medullary interactions under development and in health and disease.
Identifiants
pubmed: 33798635
pii: S0303-7207(21)00102-7
doi: 10.1016/j.mce.2021.111258
pii:
doi:
Substances chimiques
Catecholamines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111258Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.