Monepantel pharmaco-therapeutic evaluation in cattle: Pattern of efficacy against multidrug resistant nematodes.
Cattle
Monepantel
Pharmaco-parasitological assessment
Resistant nematodes
Journal
International journal for parasitology. Drugs and drug resistance
ISSN: 2211-3207
Titre abrégé: Int J Parasitol Drugs Drug Resist
Pays: Netherlands
ID NLM: 101576715
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
16
10
2020
revised:
11
03
2021
accepted:
15
03
2021
pubmed:
3
4
2021
medline:
12
10
2021
entrez:
2
4
2021
Statut:
ppublish
Résumé
The goal of the current work was to perform an integrated evaluation of monepantel (MNP) pharmacokinetics (PK) and pharmacodynamics, measured as anthelmintic efficacy, after its oral administration to calves naturally infected with GI nematodes resistant to ivermectin (IVM) and ricobendazole (RBZ) on three commercial farms. On each farm, forty-five calves were randomly allocated into three groups (n = 15): MNP oral administration (2.5 mg/kg); IVM subcutaneous (SC) administration (0.2 mg/kg); and RBZ SC administration (3.75 mg/kg). Eight animals from the MNP treated group (Farm 1) were selected to perform the PK study. Drug concentrations were measured by HPLC. The efficacy was determined by the faecal egg count reduction test (FECRT). MNP and MNP-sulphone (MNPSO
Identifiants
pubmed: 33799058
pii: S2211-3207(21)00013-0
doi: 10.1016/j.ijpddr.2021.03.003
pmc: PMC8044591
pii:
doi:
Substances chimiques
Anthelmintics
0
Aminoacetonitrile
3739OQ10IJ
Ivermectin
70288-86-7
monepantel
82MA79VJ33
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
162-167Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.