Membranous Nephropathy: From Research Bench to Personalized Care.
PLA2R
glomerulonephritis
membranous nephropathy
personalized medicine
proteomics
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
14 Mar 2021
14 Mar 2021
Historique:
received:
26
01
2021
revised:
15
02
2021
accepted:
08
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
Membranous nephropathy is a glomerulopathy that causes nephrotic syndrome and, in at least a third of cases, lasting end-stage kidney disease (ESKD). It is also a rare case of revolutionary changes in our understanding of the disease, that translates from scientific findings to real diagnosis and treatment recommendations in less than ten years. In this review we present: (1) a short history and traditional approach to patients with membranous nephropathy, (2) current recommendations and treatment options that have emerged in recent years, (3) findings of new studies, with a particular focus on serological/immunological methods, genomic and proteomic studies, still requiring validation. With further development in this field, membranous nephropathy may become one of the first nephrological conditions that apply a truly personalized approach with the omission of invasive measures such as kidney biopsy.
Identifiants
pubmed: 33799372
pii: jcm10061205
doi: 10.3390/jcm10061205
pmc: PMC7998937
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NIH/NIDDK
ID : 2U01DK100876
Organisme : NIH/NIDDK
ID : 1RC2DK116690
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