A Nation-Wide, Multi-Center Study on the Quality of Life of ALS Patients in Germany.

ALS treatment Amyotrophic Lateral Sclerosis (ALS) Amyotrophic Lateral Sclerosis Assessment Questionnaire 5 (ALSAQ-5) EuroQol Five Dimension Five Level Scale (EQ-5D-5L) assistive devices health-related quality of life (HRQoL) quality of life (QoL) symptom-specific treatment “bulbar-onset” ALS (bALS) “limb-onset” ALS (lALS)

Journal

Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646

Informations de publication

Date de publication:
14 Mar 2021
Historique:
received: 10 02 2021
revised: 09 03 2021
accepted: 10 03 2021
entrez: 3 4 2021
pubmed: 4 4 2021
medline: 4 4 2021
Statut: epublish

Résumé

Improving quality of life (QoL) is central to amyotrophic lateral sclerosis (ALS) treatment. This Germany-wide, multicenter cross-sectional study analyses the impact of different symptom-specific treatments and ALS variants on QoL. Health-related QoL (HRQoL) in 325 ALS patients was assessed using the Amyotrophic Lateral Sclerosis Assessment Questionnaire 5 (ALSAQ-5) and EuroQol Five Dimension Five Level Scale (EQ-5D-5L), together with disease severity (captured by the revised ALS Functional Rating Scale (ALSFRS-R)) and the current care and therapies used by our cohort. At inclusion, the mean ALSAQ-5 total score was 56.93 (max. 100, best = 0) with a better QoL associated with a less severe disease status (β = -1.96 per increase of one point in the ALSFRS-R score,

Identifiants

pubmed: 33799476
pii: brainsci11030372
doi: 10.3390/brainsci11030372
pmc: PMC7998410
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : German Neuromuscular Society "Deutsche Gesellschaft fuer Muskelkranke" e.V.
ID : Sc23/1

Références

Lancet Neurol. 2016 Oct;15(11):1182-94
pubmed: 27647646
Neurology. 2003 Jul 22;61(2):171-7
pubmed: 12874394
Neurotherapeutics. 2015 Apr;12(2):394-402
pubmed: 25502407
Front Neurol. 2019 Feb 19;10:106
pubmed: 30837936
Value Health. 2020 Dec;23(12):1543-1551
pubmed: 33248509
Amyotroph Lateral Scler. 2006 Dec;7(4):195-200
pubmed: 17127557
Rev Neurol (Paris). 2019 May;175(5):277-282
pubmed: 30606512
Amyotroph Lateral Scler Frontotemporal Degener. 2013 Jan;14(1):20-5
pubmed: 22871079
Health Qual Life Outcomes. 2016 Jul 20;14(1):107
pubmed: 27439463
Amyotroph Lateral Scler Frontotemporal Degener. 2014 Dec;15(7-8):610-7
pubmed: 25286015
Int J Med Educ. 2011 Jun 27;2:53-55
pubmed: 28029643
J Neurol. 2015 Jun;262(6):1447-54
pubmed: 25860344
J Neurol Sci. 1999 Oct 31;169(1-2):13-21
pubmed: 10540002
J Neurol Neurosurg Psychiatry. 2017 Oct;88(10):825-831
pubmed: 28572273
J Neurol. 2013 Sep;260(9):2242-55
pubmed: 23736973
J Multidiscip Healthc. 2017 May 19;10:205-215
pubmed: 28579792
J Neurol Sci. 2000 Nov 1;180(1-2):94-100
pubmed: 11090872
Dtsch Arztebl Int. 2008 Jun;105(23):397-403
pubmed: 19626161
J Neurol. 2020 Dec;267(12):3593-3601
pubmed: 32638110
Trauma Surg Acute Care Open. 2018 Sep 19;3(1):e000180
pubmed: 30246152
J Clin Epidemiol. 2018 Jun;98:146-151
pubmed: 29258908
Cochrane Database Syst Rev. 2012 Mar 14;(3):CD001447
pubmed: 22419278
Neurology. 2016 Jun 14;86(24):2271-7
pubmed: 27164661
Dysphagia. 2017 Dec;32(6):734-747
pubmed: 28664472
Orphanet J Rare Dis. 2016 May 04;11(1):58
pubmed: 27145956
J Neurol Neurosurg Psychiatry. 2020 Jul;91(7):783-785
pubmed: 32317400
Amyotroph Lateral Scler. 2007 Apr;8(2):96-100
pubmed: 17453637
Eur J Neurol. 2012 Mar;19(3):360-75
pubmed: 21914052
Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(5-6):291-2
pubmed: 26121170
Clin Nutr. 2020 Oct;39(10):3112-3118
pubmed: 32063408
J Neurol Neurosurg Psychiatry. 2015 Jan;86(1):45-9
pubmed: 24463480
Swiss Med Wkly. 2013 Aug 07;143:w13830
pubmed: 23925784
Muscle Nerve. 2012 Jul;46(1):9-25
pubmed: 22644588
Qual Life Res. 2011 Dec;20(10):1727-36
pubmed: 21479777
Funct Neurol. 2013 Apr-May;28(2):115-9
pubmed: 24125561
Palliat Support Care. 2015 Dec;13(6):1603-14
pubmed: 25851240
Neurol Res. 2010 Feb;32(1):32-40
pubmed: 20092693
Value Health. 2012 Jul-Aug;15(5):708-15
pubmed: 22867780
Degener Neurol Neuromuscul Dis. 2019 Mar 20;9:19-26
pubmed: 31118868
Neurosci Biobehav Rev. 2017 Apr;75:378-392
pubmed: 28163193
BMC Neurol. 2015 May 16;15:84
pubmed: 25982050
Surg Neurol Int. 2015 Nov 16;6:171
pubmed: 26629397
PLoS One. 2015 Oct 30;10(10):e0141500
pubmed: 26517122
Clin Rehabil. 2007 Mar;21(3):266-72
pubmed: 17329284
Orphanet J Rare Dis. 2009 Feb 03;4:3
pubmed: 19192301
Neurol Neurochir Pol. 2010 Nov-Dec;44(6):560-6
pubmed: 21225518
Ann Neurol. 2017 Feb;81(2):310-315
pubmed: 28074605
Amyotroph Lateral Scler Frontotemporal Degener. 2018 May;19(3-4):212-219
pubmed: 29092645
Lancet Neurol. 2006 Feb;5(2):140-7
pubmed: 16426990
J Neurol. 2010 Sep;257(9):1473-81
pubmed: 20383521
Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Jun;5(2):84-98
pubmed: 15204010
Sleep Med. 2007 Nov;8(7-8):733-41
pubmed: 17512797
Eur J Health Econ. 2019 Aug;20(6):933-944
pubmed: 31030292
Eur J Neurol. 2021 Apr;28(4):1160-1171
pubmed: 33210770
Value Health. 2020 Jun;23(6):760-767
pubmed: 32540234
Behav Sci (Basel). 2020 Jan 10;10(1):
pubmed: 31936812
Cochrane Database Syst Rev. 2017 Oct 06;10:CD004427
pubmed: 28982219
Lancet. 2011 Mar 12;377(9769):942-55
pubmed: 21296405
J Neurol Sci. 2016 Nov 15;370:269-273
pubmed: 27772773
Amyotroph Lateral Scler. 2011 Mar;12(2):105-8
pubmed: 20653520
Amyotroph Lateral Scler Frontotemporal Degener. 2013 Mar;14(2):116-23
pubmed: 23039060
Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Dec;5(4):235-9
pubmed: 15799553
Amyotroph Lateral Scler Frontotemporal Degener. 2016 Jul-Aug;17(5-6):337-42
pubmed: 27046344
Parkinsonism Relat Disord. 2007 Mar;13(2):108-14
pubmed: 17055326
Neurol Ther. 2014 Jun 17;3(1):15-28
pubmed: 26000221
J Crit Care. 2011 Jun;26(3):329.e7-14
pubmed: 20655697
Int J Surg. 2014 Dec;12(12):1495-9
pubmed: 25046131
Orphanet J Rare Dis. 2020 Jun 12;15(1):149
pubmed: 32532288
J Pain Symptom Manage. 2003 Oct;26(4):890-6
pubmed: 14527757
J Neurol Sci. 2001 Oct 15;191(1-2):87-93
pubmed: 11676997
Amyotroph Lateral Scler Frontotemporal Degener. 2014 Jun;15(3-4):279-84
pubmed: 24720420
Amyotroph Lateral Scler. 2009 Oct-Dec;10(5-6):310-23
pubmed: 19922118
Int J Psychol. 2013;48(3):194-205
pubmed: 22731673
Amyotroph Lateral Scler Frontotemporal Degener. 2014 Mar;15(1-2):55-61
pubmed: 24266679
J Neurol. 2017 Apr;264(4):749-757
pubmed: 28220290

Auteurs

Tara Peseschkian (T)

Department of Neurology, Hannover Medical School, 30625 Hannover, Germany.

Isabell Cordts (I)

Department of Neurology, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany.

René Günther (R)

Department of Neurology, University Hospital Carl Gustav Carus, 01307 Dresden, Germany.
German Center for Neurodegenerative Diseases (DZNE), 01307 Dresden, Germany.

Benjamin Stolte (B)

Department of Neurology, University Medicine Essen, 45147 Essen, Germany.

Daniel Zeller (D)

Department of Neurology, University of Würzburg, 97080 Würzburg, Germany.

Carsten Schröter (C)

Hoher Meißner Clinic, Neurology, 37242 Bad Sooden-Allendorf, Germany.

Ute Weyen (U)

Department of Neurology, Ruhr-University Bochum, BG-Kliniken Bergmannsheil, 44789 Bochum, Germany.

Martin Regensburger (M)

Department of Molecular Neurology, Friedrich-Alexander-University Erlangen-Nürnberg, 91054 Erlangen, Germany.

Joachim Wolf (J)

Department of Neurology, Diakonissen Hospital Mannheim, 68163 Mannheim, Germany.

Ilka Schneider (I)

Department of Neurology, Martin-Luther University Halle/Saale, 06120 Halle, Germany.
Department of Neurology, Klinikum Sankt Georg, 04129 Leipzig, Germany.

Andreas Hermann (A)

Translational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany.
German Center for Neurodegenerative Diseases Rostock/Greifswald, 18147 Rostock, Germany.

Moritz Metelmann (M)

Department of Neurology, University Hospital Leipzig, 04103 Leipzig, Germany.

Zacharias Kohl (Z)

Department of Neurology, University of Regensburg, 93053 Regensburg, Germany.

Ralf A Linker (RA)

Department of Neurology, University of Regensburg, 93053 Regensburg, Germany.

Jan Christoph Koch (JC)

Department of Neurology, University Medicine Göttingen, 37075 Göttingen, Germany.

Boriana Büchner (B)

Friedrich-Baur Institute, Department of Neurology, University Hospital, Ludwig Maximilian University of Munich, 80336 Munich, Germany.

Ulrike Weiland (U)

Department of Neurology, University of Ulm, 89081 Ulm, Germany.

Erik Schönfelder (E)

Department of Neurology, Hannover Medical School, 30625 Hannover, Germany.

Felix Heinrich (F)

Department of Neurology, Hannover Medical School, 30625 Hannover, Germany.

Alma Osmanovic (A)

Department of Neurology, Hannover Medical School, 30625 Hannover, Germany.

Thomas Klopstock (T)

Friedrich-Baur Institute, Department of Neurology, University Hospital, Ludwig Maximilian University of Munich, 80336 Munich, Germany.
Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany.
German Center for Neurodegenerative Diseases (DZNE), 80336 Munich, Germany.

Johannes Dorst (J)

Department of Neurology, University of Ulm, 89081 Ulm, Germany.

Albert C Ludolph (AC)

Department of Neurology, University of Ulm, 89081 Ulm, Germany.
German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, Germany.

Matthias Boentert (M)

Department of Neurology with the Institute of Translational Neurology, University Hospital Münster, 48149 Münster, Germany.
Department of Medicine, UKM Marienhospital, 48565 Steinfurt, Germany.

Tim Hagenacker (T)

Department of Neurology, University Medicine Essen, 45147 Essen, Germany.

Marcus Deschauer (M)

Department of Neurology, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany.

Paul Lingor (P)

Department of Neurology, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany.

Susanne Petri (S)

Department of Neurology, Hannover Medical School, 30625 Hannover, Germany.

Olivia Schreiber-Katz (O)

Department of Neurology, Hannover Medical School, 30625 Hannover, Germany.

Classifications MeSH