Non-Syndromic Intellectual Disability and Its Pathways: A Long Noncoding RNA Perspective.
long noncoding RNA
molecular and cellular pathways
neural function
neurodevelopment
non-syndromic intellectual disability
Journal
Non-coding RNA
ISSN: 2311-553X
Titre abrégé: Noncoding RNA
Pays: Switzerland
ID NLM: 101652294
Informations de publication
Date de publication:
11 Mar 2021
11 Mar 2021
Historique:
received:
12
11
2020
revised:
05
12
2020
accepted:
07
12
2020
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
Non-syndromic intellectual disability (NS-ID or idiopathic) is a complex neurodevelopmental disorder that represents a global health issue. Although many efforts have been made to characterize it and distinguish it from syndromic intellectual disability (S-ID), the highly heterogeneous aspect of this disorder makes it difficult to understand its etiology. Long noncoding RNAs (lncRNAs) comprise a large group of transcripts that can act through various mechanisms and be involved in important neurodevelopmental processes. In this sense, comprehending the roles they play in this intricate context is a valuable way of getting new insights about how NS-ID can arise and develop. In this review, we attempt to bring together knowledge available in the literature about lncRNAs involved with molecular and cellular pathways already described in intellectual disability and neural function, to better understand their relevance in NS-ID and the regulatory complexity of this disorder.
Identifiants
pubmed: 33799572
pii: ncrna7010022
doi: 10.3390/ncrna7010022
pmc: PMC8005948
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 001
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 465539/2014-9
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2009/53853-5
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2013/08135-2
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