Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma.
Animals
Antineoplastic Agents
/ therapeutic use
Biomarkers, Tumor
/ genetics
Brain Neoplasms
/ genetics
Cell Lineage
Drug Resistance, Neoplasm
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Glioblastoma
/ genetics
Humans
Neoplastic Stem Cells
/ drug effects
Phenotype
Radiation Tolerance
Tumor Microenvironment
cancer
cancer stem cells
glioblastoma
glioma
glioma stem cells
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
11 03 2021
11 03 2021
Historique:
received:
28
01
2021
revised:
27
02
2021
accepted:
09
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Cancer stem cells (CSCs), known also as tumor-initiating cells, are quiescent, pluripotent, self-renewing neoplastic cells that were first identified in hematologic tumors and soon after in solid malignancies. CSCs have attracted remarkable research interest due to their role in tumor resistance to chemotherapy and radiation treatment as well as recurrence. Extensive research has been devoted to the role of CSCs in glioblastoma multiforme (GBM), the most common primary brain tumor in adults, which is characterized by a dismal prognosis because of its aggressive course and poor response to treatment. The aim of the current paper is to provide an overview of current knowledge on the role of cancer stem cells in the pathogenesis and treatment resistance of glioblastoma. The six regulatory mechanisms of glioma stem cells (GSCs)-tumor microenvironment, niche concept, metabolism, immunity, genetics, and epigenetics-are reviewed. The molecular markers used to identify GSCs are described. The role of GSCs in the treatment resistance of glioblastoma is reviewed, along with future treatment options targeting GSCs. Stem cells of glioblastoma thus represent both a driving mechanism of major treatment difficulties and a possible target for more effective future approaches.
Identifiants
pubmed: 33799798
pii: cells10030621
doi: 10.3390/cells10030621
pmc: PMC8000844
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Biomarkers, Tumor
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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