Improvement of Platelet Respiration by Cell-Permeable Succinate in Diabetic Patients Treated with Statins.
cell–permeable succinate (NV118)
diabetes
high–resolution respirometry
mitochondria
platelets
statins
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
28 Mar 2021
28 Mar 2021
Historique:
received:
02
02
2021
revised:
20
03
2021
accepted:
24
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
Diabetes mellitus (DM) is the most severe metabolic disease that reached the level of a global pandemic and is associated with high cardiovascular morbidity. Statins are the first-line lipid-lowering therapy in diabetic patients with or without a history of atherosclerotic disease. Although well tolerated, chronic treatment may result in side effects that lead to treatment interruption. Mitochondrial dysfunction has emerged as a central pathomechanism in DM- and statin-induced side effects. Assessment of mitochondrial respiration in peripheral platelets has been increasingly used as a mirror of organ mitochondrial dysfunction. The present study aimed to assess the: (i) changes in mitochondrial respiration elicited by statins in patients with type 2 DM and (ii) the effects of cell-permeable succinate (NV118) on respiratory parameters in platelets harvested from these patients. No significant changes were found in global mitochondrial respiration of intact platelets isolated from diabetic patients treated with either atorvastatin or rosuvastatin. Similarly, no significant changes in mitochondrial respiration of permeabilized platelets were found between diabetic patients treated with atorvastatin and healthy controls. Acute ex vivo administration of NV118 significantly improved respiration in isolated platelets. These results prompt further research on the role of permeable succinate as a therapeutic alternative for improving mitochondrial function in metabolic pathologies and point to the role of peripheral platelets as a potential biomarker of treatment response.
Identifiants
pubmed: 33800630
pii: life11040288
doi: 10.3390/life11040288
pmc: PMC8065590
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Circ Res. 2019 Jan 18;124(2):328-350
pubmed: 30653440
Curr Atheroscler Rep. 2013 Jan;15(1):291
pubmed: 23225173
Diabetologia. 2007 Apr;50(4):790-6
pubmed: 17334651
Int J Mol Sci. 2021 Jan 03;22(1):
pubmed: 33401621
J Clin Endocrinol Metab. 2018 Jan 1;103(1):75-84
pubmed: 29040646
Antioxid Redox Signal. 2010 Apr;12(4):537-77
pubmed: 19650713
Eur Heart J. 2012 Jul;33(13):1635-701
pubmed: 22555213
Proc Biol Sci. 2015 Aug 7;282(1812):20151028
pubmed: 26203001
J Clin Med. 2017 Jul 25;6(8):
pubmed: 28757597
Diabetes. 2007 Jun;56(6):1592-9
pubmed: 17351150
Bratisl Lek Listy. 2019;120(9):630-635
pubmed: 31475544
Pharmacol Res. 2020 Apr;154:104201
pubmed: 30877064
Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E268-E285
pubmed: 30601700
Curr Cardiol Rep. 2013 Sep;15(9):397
pubmed: 23888382
Physiol Res. 2019 Jun 30;68(3):347-363
pubmed: 30904011
Methodist Debakey Cardiovasc J. 2019 Jan-Mar;15(1):23-31
pubmed: 31049146
Int J Biochem Cell Biol. 2009 Oct;41(10):1837-45
pubmed: 19467914
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8466-71
pubmed: 12832613
J Clin Res Pediatr Endocrinol. 2017 Oct 30;10(2):92-99
pubmed: 29082895
Eur Heart J. 2018 Jul 14;39(27):2526-2539
pubmed: 29718253
Clin Pharmacokinet. 2000 Aug;39(2):99-116
pubmed: 10976657
Biomed Res Int. 2014;2014:238463
pubmed: 24818134
Basic Clin Pharmacol Toxicol. 2017 Feb;120(2):131-137
pubmed: 27553485
Am J Physiol. 1998 Aug;275(2):E197-206
pubmed: 9688619
Genet Med. 2014 Nov;16(11):810-9
pubmed: 24810685
Diabetes Ther. 2016 Jun;7(2):203-19
pubmed: 27056202
Toxicol Appl Pharmacol. 2004 Jan 1;194(1):10-23
pubmed: 14728975
Int J Mol Sci. 2020 Sep 08;21(18):
pubmed: 32911736
Sci Rep. 2020 Oct 12;10(1):17012
pubmed: 33046789
Eur Heart J. 2012 Jun;33(11):1397-407
pubmed: 21775390
PLoS One. 2020 Apr 6;15(4):e0231173
pubmed: 32251487
J Diabetes Investig. 2010 Oct 19;1(5):161-9
pubmed: 24843427
Arch Med Sci. 2019 Dec 06;16(1):1-7
pubmed: 32051699
Clin Pharmacokinet. 2003;42(13):1141-60
pubmed: 14531725
Adv Enzymol Relat Subj Biochem. 1956;17:65-134
pubmed: 13313307
Drug Discov Today. 2017 Jan;22(1):85-96
pubmed: 27634340
Toxicol Mech Methods. 2009 Jan;19(1):44-50
pubmed: 19778232
Nat Commun. 2016 Aug 09;7:12317
pubmed: 27502960
BMJ. 2000 Oct 21;321(7267):971-2
pubmed: 11039939
Exp Clin Endocrinol Diabetes. 2012 Apr;120(4):248-51
pubmed: 21922457
J Clin Endocrinol Metab. 2009 Apr;94(4):1372-8
pubmed: 19141588
Endocr Rev. 2010 Jun;31(3):364-95
pubmed: 20156986
Int J Mol Sci. 2020 Feb 21;21(4):
pubmed: 32098258
Int J Mol Sci. 2020 Jul 09;21(14):
pubmed: 32660144
Physiol Res. 2016 Nov 23;65(5):777-788
pubmed: 27429121
Front Cardiovasc Med. 2020 Feb 18;7:12
pubmed: 32133373
J Avian Med Surg. 2015 Mar;29(1):18-24
pubmed: 25867662
Eur Heart J. 2015 May 1;36(17):1012-22
pubmed: 25694464
Life (Basel). 2020 Dec 14;10(12):
pubmed: 33327428
South Med J. 2018 Jan;111(1):39-44
pubmed: 29298368
Expert Opin Drug Metab Toxicol. 2015;11(9):1435-47
pubmed: 26058399
Eur Heart J. 2020 Sep 14;41(35):3336-3342
pubmed: 32702748
Br J Clin Pharmacol. 2011 Jul;72(1):164-5
pubmed: 21223360
Mitochondrion. 2013 Jan;13(1):7-14
pubmed: 23164798
N Engl J Med. 2004 Feb 12;350(7):664-71
pubmed: 14960743
Circulation. 2013 Jan 15;127(2):251-7
pubmed: 23319813
Biochem Biophys Res Commun. 2005 Apr 15;329(3):1067-75
pubmed: 15752763
Am J Cardiol. 2013 Apr 15;111(8):1123-30
pubmed: 23352266
Br J Haematol. 2003 Jun;121(6):892-6
pubmed: 12786800
Cell Mol Life Sci. 2006 Oct;63(19-20):2415-25
pubmed: 17013560
Eur Heart J. 2020 Jan 1;41(1):111-188
pubmed: 31504418
Arch Med Sci. 2012 Feb 29;8(1):1-3
pubmed: 22457664
Arch Med Sci. 2013 Aug 30;9(4):585-8
pubmed: 24049514
Pharmacol Ther. 2017 Jul;175:1-16
pubmed: 28223230
Free Radic Biol Med. 2019 May 20;136:172-182
pubmed: 30625393
Diabetes. 2004 Feb;53 Suppl 1:S96-102
pubmed: 14749273
Mol Metab. 2015 Jul 15;4(9):631-42
pubmed: 26413469
Arch Med Sci. 2016 Jun 1;12(3):645-58
pubmed: 27279860
Antioxid Redox Signal. 2014 Mar 10;20(8):1300-12
pubmed: 23992095
Intensive Care Med Exp. 2018 Aug 1;6(1):22
pubmed: 30069806