Mechanisms Underlying Connexin Hemichannel Activation in Disease.
Animals
Cell Death
Cell Membrane
/ metabolism
Connexin 43
/ metabolism
Connexins
/ metabolism
Cytosol
/ metabolism
Gap Junctions
/ physiology
Homeostasis
Humans
Hydrogen-Ion Concentration
Inflammation
/ metabolism
Pathogen-Associated Molecular Pattern Molecules
Peptides
/ chemistry
Phosphorylation
Stress, Mechanical
connexin hemichannel
mechanism
pathology
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Mar 2021
28 Mar 2021
Historique:
received:
15
03
2021
revised:
22
03
2021
accepted:
26
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
9
7
2021
Statut:
epublish
Résumé
Gap junctions and connexin hemichannels mediate intercellular and extracellular communication, respectively. While gap junctions are seen as the "good guys" by controlling homeostasis, connexin hemichannels are considered as the "bad guys", as their activation is associated with the onset and dissemination of disease. Open connexin hemichannels indeed mediate the transport of messengers between the cytosol and extracellular environment and, by doing so, fuel inflammation and cell death in a plethora of diseases. The present mini-review discusses the mechanisms involved in the activation of connexin hemichannels during pathology.
Identifiants
pubmed: 33800706
pii: ijms22073503
doi: 10.3390/ijms22073503
pmc: PMC8036530
pii:
doi:
Substances chimiques
Connexin 43
0
Connexins
0
Pathogen-Associated Molecular Pattern Molecules
0
Peptides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Research Council
ID : 861913
Pays : International
Organisme : University Hospital of the Vrije Universiteit Brussel-Belgium
ID : Willy Gepts Fund
Organisme : Horizon 2020
ID : 858014
Organisme : Fonds Wetenschappelijk Onderzoek
ID : G012318N, G020018N and G0F7219N
Références
Cell Calcium. 2009 Sep;46(3):176-87
pubmed: 19656565
J Cereb Blood Flow Metab. 2011 Sep;31(9):1942-57
pubmed: 21654699
Front Physiol. 2017 Aug 23;8:600
pubmed: 28878685
Biomolecules. 2020 Aug 23;10(9):
pubmed: 32842488
Front Physiol. 2014 Mar 31;5:113
pubmed: 24744733
Front Immunol. 2018 Aug 15;9:1899
pubmed: 30158937
Biol Cell. 2013 Sep;105(9):373-98
pubmed: 23718186
J Cell Sci. 2018 Mar 21;131(6):
pubmed: 29487175
Basic Res Cardiol. 2013 Jan;108(1):309
pubmed: 23184389
Oncotarget. 2017 Dec 14;9(6):7204-7218
pubmed: 29467962
Elife. 2019 Feb 08;8:
pubmed: 30735126
Biomolecules. 2021 Jan 06;11(1):
pubmed: 33418902
Mol Biol Cell. 2005 Jul;16(7):3100-6
pubmed: 15843434
Pharmacol Ther. 2015 Sep;153:90-106
pubmed: 26073311
Crit Rev Biochem Mol Biol. 2016 Nov/Dec;51(6):413-439
pubmed: 27387655
Biochim Biophys Acta Mol Basis Dis. 2021 Apr 1;1867(4):166047
pubmed: 33418036
Front Physiol. 2019 Feb 27;10:141
pubmed: 30873043
Int J Mol Sci. 2018 Aug 21;19(9):
pubmed: 30134552
Front Immunol. 2017 Jan 25;8:36
pubmed: 28179906
Am J Physiol Cell Physiol. 2010 Dec;299(6):C1504-15
pubmed: 20881238
Cell Physiol Biochem. 2018;45(6):2369-2388
pubmed: 29587265
Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3980-4
pubmed: 11891346
Pflugers Arch. 2008 Jun;456(3):519-27
pubmed: 18172602
Biochim Biophys Acta Biomembr. 2018 Jan;1860(1):22-39
pubmed: 28476631
Arch Toxicol. 2015 Jan;89(1):143-5
pubmed: 25430036
Cell Death Dis. 2019 Feb 12;10(2):128
pubmed: 30755589
J Biol Chem. 2006 Jul 28;281(30):21362-21368
pubmed: 16720574
J Biol Chem. 2014 Aug 1;289(31):21519-32
pubmed: 24939841
PLoS One. 2007 Aug 08;2(8):e712
pubmed: 17684558
Drug Discov Today. 2019 Aug;24(8):1627-1636
pubmed: 30690195
Cell Commun Signal. 2020 May 25;18(1):79
pubmed: 32450899
Biochim Biophys Acta. 2012 May;1818(5):1148-57
pubmed: 22285739
J Biol Chem. 2007 Oct 12;282(41):30171-80
pubmed: 17693411
Mol Biol Cell. 2007 Jan;18(1):34-46
pubmed: 17079735
EMBO J. 2006 Jan 11;25(1):34-44
pubmed: 16341088
FASEB J. 2006 Nov;20(13):2329-38
pubmed: 17077310
Cell Death Dis. 2020 Mar 18;11(3):194
pubmed: 32188841
Trends Biochem Sci. 2016 Dec;41(12):1012-1021
pubmed: 27669650
Expert Rev Mol Med. 2009 Nov 19;11:e35
pubmed: 19939300
J Neurosci. 2007 Dec 12;27(50):13781-92
pubmed: 18077690
Cell Signal. 2006 May;18(5):592-600
pubmed: 16183253
Hepatology. 2019 Mar;69(3):1317-1323
pubmed: 30300925
Int J Mol Sci. 2021 Feb 15;22(4):
pubmed: 33672031
J Biol Chem. 2014 Apr 11;289(15):10582-10591
pubmed: 24563481
Sci Rep. 2017 Aug 15;7(1):8268
pubmed: 28811572
J Bone Miner Res. 1996 Jan;11(1):62-71
pubmed: 8770698
Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):E7986-E7995
pubmed: 27872296
Brain Res Brain Res Rev. 2000 Apr;32(1):192-202
pubmed: 10751670
J Biol Chem. 2008 Sep 26;283(39):26374-82
pubmed: 18676366
J Invest Dermatol. 2015 Apr;135(4):1033-1042
pubmed: 25229253
Ther Adv Musculoskelet Dis. 2014 Jun;6(3):79-91
pubmed: 24891879
J Biol Chem. 2005 Mar 18;280(11):10646-54
pubmed: 15615707
Biochim Biophys Acta Mol Basis Dis. 2021 Jun 1;1867(6):166115
pubmed: 33711451
Curr Osteoporos Rep. 2012 Jun;10(2):118-25
pubmed: 22552701
FEBS Lett. 2014 Apr 17;588(8):1304-14
pubmed: 24607543
Exp Eye Res. 2021 Jan;202:108384
pubmed: 33285185
Biochim Biophys Acta. 2013 Jan;1828(1):157-66
pubmed: 22609170
Curr Neuropharmacol. 2009 Mar;7(1):65-74
pubmed: 19721819
Cell Death Differ. 2009 Apr;16(4):524-36
pubmed: 19197295
CNS Neurol Disord Drug Targets. 2013 Aug;12(5):698-714
pubmed: 23469845
Prog Biophys Mol Biol. 2020 Jul;153:35-41
pubmed: 32220599
Front Pharmacol. 2017 Sep 25;8:661
pubmed: 28993732
Front Physiol. 2020 Jan 20;10:1574
pubmed: 32038277
PLoS One. 2012;7(2):e32531
pubmed: 22393412
J Biol Chem. 2015 Nov 20;290(47):28321-28328
pubmed: 26442583
Sci Rep. 2019 Nov 12;9(1):16623
pubmed: 31719598
Sci Rep. 2017 May 22;7(1):2243
pubmed: 28533546
Eur J Med Chem. 2020 Oct 1;203:112602
pubmed: 32679454
BMC Cell Biol. 2016 May 24;17 Suppl 1:11
pubmed: 27229925
Pharmacol Ther. 2017 Dec;180:144-160
pubmed: 28720428
Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):16030-5
pubmed: 14663144
Biochem Pharmacol. 2003 Oct 15;66(8):1661-72
pubmed: 14555247
Osteoporos Int. 1993;3 Suppl 1:136-40
pubmed: 8461541
J Bone Miner Res. 2013 Jul;28(7):1611-21
pubmed: 23456878
Mil Med Res. 2015 May 19;2:12
pubmed: 26045969
Front Physiol. 2014 Feb 25;5:71
pubmed: 24611052
Molecules. 2017 Nov 25;22(12):
pubmed: 29186829
Cell Mol Life Sci. 2015 Aug;72(15):2775-8
pubmed: 26084871
Int J Mol Sci. 2019 Jul 06;20(13):
pubmed: 31284572
Yonsei Med J. 2015 Jan;56(1):1-15
pubmed: 25510741
Cell Death Differ. 2009 Jan;16(1):151-63
pubmed: 18820645
Brain Res Brain Res Rev. 2004 Dec;47(1-3):290-303
pubmed: 15572178
J Toxicol Environ Health B Crit Rev. 2020 Aug 17;23(6):255-275
pubmed: 32568623
Cell Calcium. 2011 Sep;50(3):211-21
pubmed: 21459443
J Membr Biol. 2012 Jun;245(5-6):319-32
pubmed: 22739962
J Clin Invest. 2021 Apr 1;131(7):
pubmed: 33621213
J Neurophysiol. 2015 Nov;114(5):3014-22
pubmed: 26400258
World Allergy Organ J. 2012 Jan;5(1):9-19
pubmed: 23268465
Expert Opin Drug Discov. 2020 Oct;15(10):1213-1222
pubmed: 32539572