Bioactive Triterpenes of
Anticholesteremic Agents
/ isolation & purification
Catalytic Domain
/ drug effects
Cholesterol
/ metabolism
Chromatography, High Pressure Liquid
Dietary Supplements
Drug Evaluation, Preclinical
Flame Ionization
Gas Chromatography-Mass Spectrometry
Hepatocytes
/ drug effects
Humans
Hydrogen
/ chemistry
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/ pharmacology
Lovastatin
/ pharmacology
Models, Molecular
Molecular Docking Simulation
Plant Gums
/ chemistry
Protein Conformation
Resins, Plant
/ chemistry
Triterpenes
/ isolation & purification
HMGCR
PCSK9
PPARα
breu branco
enzymatic activity
gene expression
hypercholesterolemia
molecular docking
monacolin
statin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Mar 2021
06 Mar 2021
Historique:
received:
03
02
2021
revised:
25
02
2021
accepted:
02
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Hypercholesterolemia is one of the major causes of cardiovascular disease, the risk of which is further increased if other forms of dyslipidemia occur. Current therapeutic strategies include changes in lifestyle coupled with drug administration. Statins represent the most common therapeutic approach, but they may be insufficient due to the onset of resistance mechanisms and side effects. Consequently, patients with mild hypercholesterolemia prefer the use of food supplements since these are perceived to be safer. Here, we investigate the phytochemical profile and cholesterol-lowering potential of
Identifiants
pubmed: 33800828
pii: ijms22052664
doi: 10.3390/ijms22052664
pmc: PMC7961947
pii:
doi:
Substances chimiques
Anticholesteremic Agents
0
Hydroxymethylglutaryl-CoA Reductase Inhibitors
0
Plant Gums
0
Resins, Plant
0
Triterpenes
0
Hydrogen
7YNJ3PO35Z
Cholesterol
97C5T2UQ7J
Lovastatin
9LHU78OQFD
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Int J Mol Med. 2011 Jan;27(1):103-10
pubmed: 21069265
Nucleic Acids Res. 2001 May 1;29(9):e45
pubmed: 11328886
Inflammopharmacology. 2008 Feb;16(1):48-52
pubmed: 18046512
Biomed Chromatogr. 2006 Mar;20(3):282-93
pubmed: 16143964
Food Res Int. 2018 Jan;103:130-149
pubmed: 29389599
Bioinformatics. 2020 Mar 1;36(5):1562-1569
pubmed: 31605102
Planta Med. 2006 Jan;72(1):34-9
pubmed: 16450293
Molecules. 2020 Aug 26;25(17):
pubmed: 32859023
Nutrients. 2020 Apr 03;12(4):
pubmed: 32260055
Lipids Health Dis. 2012 Aug 06;11:98
pubmed: 22867128
Appl Physiol Nutr Metab. 2017 Jan;42(1):23-32
pubmed: 27911087
J Cheminform. 2016 Jan 29;8:3
pubmed: 26834843
Atherosclerosis. 2015 Jun;240(2):415-23
pubmed: 25897793
J Mol Graph Model. 2009 Nov;28(4):336-46
pubmed: 19767223
J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 5;791(1-2):21-30
pubmed: 12798161
Nat Prod Res. 2020 Aug;34(16):2378-2383
pubmed: 30499330
Exp Dermatol. 2006 Jan;15(1):66-73
pubmed: 16364033
Medicines (Basel). 2017 Dec 01;4(4):
pubmed: 29194388
Pract Neurol. 2018 Apr;18(2):97-105
pubmed: 29496886
Fundam Clin Pharmacol. 2005 Feb;19(1):117-25
pubmed: 15660968
Chem Biol Drug Des. 2006 Jan;67(1):83-4
pubmed: 16492153
Front Plant Sci. 2020 Jun 17;11:836
pubmed: 32625226
Anticancer Res. 2002 Nov-Dec;22(6A):3309-18
pubmed: 12530080
J Comput Aided Mol Des. 2013 Mar;27(3):221-34
pubmed: 23579614
Phytomedicine. 2003 Mar;10(2-3):115-21
pubmed: 12725563
Planta Med. 2004 Aug;70(8):780-2
pubmed: 15368675
Biomed Pharmacother. 2019 Jan;109:1860-1866
pubmed: 30551441
Neotrop Entomol. 2012 Aug;41(4):257-62
pubmed: 23950059
Ann Ig. 2017 Sep-Oct;29(5):464-480
pubmed: 28715059
Methodist Debakey Cardiovasc J. 2019 Jul-Sep;15(3):192-199
pubmed: 31687098
Food Chem Toxicol. 2017 Dec;110:130-141
pubmed: 28993214
J Herb Pharmacother. 2007;7(2):31-47
pubmed: 18285306
J Antibiot (Tokyo). 1976 Aug;29(8):841-3
pubmed: 791911
Food Chem. 2020 Mar 1;307:125515
pubmed: 31648177
Arh Hig Rada Toksikol. 2009 Dec;60(4):457-64
pubmed: 20061247
Parasitol Int. 2021 Feb;80:102179
pubmed: 32853776
J Med Chem. 2006 Oct 19;49(21):6177-96
pubmed: 17034125
Sci Rep. 2020 Nov 16;10(1):19834
pubmed: 33199761
Clin Chim Acta. 2020 Jan;500:81-86
pubmed: 31770510
Am J Cardiol. 1988 Nov 11;62(15):10J-15J
pubmed: 3055919
J Ethnopharmacol. 1999 Jul;66(1):57-69
pubmed: 10432208
J Am Coll Cardiol. 2016 May 24;67(20):2395-2410
pubmed: 27199064
Evid Based Complement Alternat Med. 2015;2015:106157
pubmed: 25709707
J Med Chem. 2006 Jan 26;49(2):534-53
pubmed: 16420040
Nat Rev Drug Discov. 2003 Jul;2(7):517-26
pubmed: 12815379
Phytomedicine. 2012 Jun 15;19(8-9):686-92
pubmed: 22554715
Nat Rev Cardiol. 2015 Oct;12(10):565-75
pubmed: 26076948
J Med Chem. 2004 Mar 25;47(7):1739-49
pubmed: 15027865
Foods. 2020 Dec 24;10(1):
pubmed: 33374394
Nutr Cancer. 2020;72(1):146-156
pubmed: 31149840
Lipids Health Dis. 2017 Oct 6;16(1):194
pubmed: 28985743
Antibiotics (Basel). 2020 Jul 11;9(7):
pubmed: 32664528
Arterioscler Thromb Vasc Biol. 2003 Jan 1;23(1):90-6
pubmed: 12524230
Cell Metab. 2011 Jan 5;13(1):44-56
pubmed: 21195348
Molecules. 2020 Nov 16;25(22):
pubmed: 33207537
BMC Complement Med Ther. 2021 Jan 1;21(1):1
pubmed: 33386071
Pharmacol Biochem Behav. 2006 Dec;85(4):827-34
pubmed: 17207523
Planta Med. 2017 Feb;83(3-04):285-291
pubmed: 27525508
Lancet Diabetes Endocrinol. 2016 Oct;4(10):850-61
pubmed: 27246162
Recent Pat Inflamm Allergy Drug Discov. 2016;10(1):21-33
pubmed: 27531153
Pharmacogn Mag. 2016 Jan;12(Suppl 1):S42-6
pubmed: 27041857
Cardiology. 1990;77 Suppl 4:14-21
pubmed: 2073667
J Pineal Res. 2019 Oct;67(3):e12598
pubmed: 31349378
Adv Clin Chem. 2015;71:171-203
pubmed: 26411415
Atherosclerosis. 2018 Oct;277:483-492
pubmed: 30270089
J Mol Graph Model. 2008 Nov;27(4):512-21
pubmed: 18986818
Anal Bioanal Chem. 2019 Oct;411(25):6655-6665
pubmed: 31410535
Food Chem Toxicol. 2014 Feb;64:403-9
pubmed: 24333398
Biochem Pharmacol. 1993 Jun 9;45(11):2203-8
pubmed: 8517861
Molecules. 2020 Jun 04;25(11):
pubmed: 32512771
Pharm Biol. 2015 Mar;53(3):407-13
pubmed: 25471298
Nucleic Acids Res. 2013 Jan;41(Database issue):D475-82
pubmed: 23193259
Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1519-28
pubmed: 20631352
Life Sci. 2005 Oct 21;77(23):2942-52
pubmed: 15964027
Ann Intern Med. 2009 Jun 16;150(12):858-68
pubmed: 19528564
Nutrients. 2020 Jun 11;12(6):
pubmed: 32545252
J Mol Biol. 2002 Jul 12;320(3):597-608
pubmed: 12096912
PLoS One. 2013 Apr 19;8(4):e62253
pubmed: 23620818
Pharm Res. 2011 Feb;28(2):405-12
pubmed: 20953676
J Comput Chem. 2005 Dec;26(16):1752-80
pubmed: 16211539
Prep Biochem Biotechnol. 2017 Oct 21;47(9):901-908
pubmed: 28816626
J Cell Mol Med. 2001 Oct-Dec;5(4):378-87
pubmed: 12067471
Plants (Basel). 2020 Oct 02;9(10):
pubmed: 33023253
Arch Intern Med. 2010 Oct 25;170(19):1722-7
pubmed: 20975018
Food Funct. 2019 Apr 17;10(4):1787-1791
pubmed: 30882807
J Med Chem. 2004 Mar 25;47(7):1750-9
pubmed: 15027866
Proteins. 2004 May 1;55(2):351-67
pubmed: 15048827
Med Hypotheses. 2016 Jan;86:138-42
pubmed: 26601593
Science. 2001 May 11;292(5519):1160-4
pubmed: 11349148
Fundam Clin Pharmacol. 2019 Feb;33(1):4-12
pubmed: 30003594
J Pharm Sci. 1991 Sep;80(9):830-4
pubmed: 1800703