Reactivations of Latent Viral Infections Are Associated with an Increased Thr389 p70S6k Phosphorylation in Peripheral Lymphocytes of Renal Transplant Recipients.
Adult
Aged
CD4-Positive T-Lymphocytes
/ immunology
Female
Humans
Kidney Transplantation
/ adverse effects
Latent Infection
/ etiology
Male
Middle Aged
Phosphorylation
Polyomavirus Infections
/ etiology
Reinfection
/ etiology
Ribosomal Protein S6 Kinases, 70-kDa
/ immunology
Transplant Recipients
/ statistics & numerical data
BK polyoma virus
PyVAN
human cytomegalovirus
p70 ribosomal S6 kinase
renal transplantation
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
06 03 2021
06 03 2021
Historique:
received:
31
01
2021
revised:
21
02
2021
accepted:
03
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
13
8
2021
Statut:
epublish
Résumé
Reactivations of BK polyoma virus (BKPyV) and human cytomegalovirus (HCMV) frequently cause life- and graft-threatening complications after renal transplantation. Both viruses are dependent on the mTOR pathway for replication. In this study we investigated the association of viral replication with mTOR activity in peripheral lymphocytes of renal transplant recipients. A flow-cytometry based assay for the measurement of Thr389 p70S6k phosphorylation, a surrogate marker of the mTOR pathway was established. Forty-eight adult renal transplant recipients were recruited to measure p70S6k activity in their peripheral blood mononuclear cells. This data set in conjunction with information concerning previous replication of BKPyV and HCMV was examined for correlations. Episodes of BKPyV replication were significantly associated with increased p70S6k phosphorylation in CD4
Identifiants
pubmed: 33800846
pii: v13030424
doi: 10.3390/v13030424
pmc: PMC8000484
pii:
doi:
Substances chimiques
Ribosomal Protein S6 Kinases, 70-kDa
EC 2.7.11.1
ribosomal protein S6 kinase, 70kD, polypeptide 2
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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