Sexual Difference Matters: Females with High Microsatellite Instability Show Increased Survival after Neoadjuvant Chemotherapy in Gastric Cancer.
adenocarcinoma
age
gastric
gastroesophageal junction
microsatellite instability
molecular subtype
neoadjuvant chemotherapy
prognosis
sex
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
02 Mar 2021
02 Mar 2021
Historique:
received:
01
02
2021
accepted:
23
02
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
We aimed to investigate patients with gastric/gastro-esophageal adenocarcinomas for sex- and age-specific differences regarding overall survival (OS) and response to neoadjuvant chemotherapy (CTx) under consideration of tumor specific molecular subtypes. Overall, 717 patients were analyzed, including 426 patients treated with and 291 treated without neoadjuvant CTx. Microsatellite instability (MSI) and Epstein-Barr virus positivity (EBV+) were determined previously. Females demonstrated a significantly increased OS (
Identifiants
pubmed: 33801374
pii: cancers13051048
doi: 10.3390/cancers13051048
pmc: PMC7958600
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Krebshilfe
ID : 70112177
Organisme : Wilhelm-Sander Stiftung
ID : 2019.156.1
Organisme : Deutsche Krebshilfe
ID : 70112380
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