Nanomagnetic Actuation of Hybrid Stents for Hyperthermia Treatment of Hollow Organ Tumors.

Brownian relaxation Néel relaxation hybrid implants hyperthermia efficiency magnetic nanoparticles stents tumor therapy

Journal

Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216

Informations de publication

Date de publication:
02 Mar 2021
Historique:
received: 29 01 2021
revised: 22 02 2021
accepted: 24 02 2021
entrez: 3 4 2021
pubmed: 4 4 2021
medline: 4 4 2021
Statut: epublish

Résumé

This paper describes a magnetic nanotechnology that locally enables hyperthermia treatment of hollow organ tumors by using polymer hybrid stents with incorporated magnetic nanoparticles (MNP). The hybrid stents are implanted and activated in an alternating magnetic field to generate therapeutically effective heat, thereby destroying the tumor. Here, we demonstrate the feasibility of nanomagnetic actuation of three prototype hybrid stents for hyperthermia treatment of hollow organ tumors. The results show that the heating efficiency of stent filaments increases with frequency from approximately 60 W/g

Identifiants

pubmed: 33801426
pii: nano11030618
doi: 10.3390/nano11030618
pmc: PMC7999083
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Bundesministerium für Wirtschaft und Energie
ID : 19735 N

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Auteurs

Benedikt Mues (B)

Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany.

Benedict Bauer (B)

Institut für Textiltechnik, RWTH Aachen University, Otto-Blumenthal-Straße 1, 52074 Aachen, Germany.

Anjali A Roeth (AA)

Department of General, Visceral and Transplant Surgery, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany.

Jeanette Ortega (J)

Institut für Textiltechnik, RWTH Aachen University, Otto-Blumenthal-Straße 1, 52074 Aachen, Germany.

Eva Miriam Buhl (EM)

Institute of Pathology, Electron Microscopy Facility, RWTH University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.

Patricia Radon (P)

Physikalisch-Technische Bundesanstalt, Abbestraße 2-12, 10587 Berlin, Germany.

Frank Wiekhorst (F)

Physikalisch-Technische Bundesanstalt, Abbestraße 2-12, 10587 Berlin, Germany.

Thomas Gries (T)

Institut für Textiltechnik, RWTH Aachen University, Otto-Blumenthal-Straße 1, 52074 Aachen, Germany.

Thomas Schmitz-Rode (T)

Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany.

Ioana Slabu (I)

Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany.

Classifications MeSH