The Impact of Melatonin and NLRP3 Inflammasome on the Expression of microRNAs in Aged Muscle.
NF-kB
NLRP3 inflammasome
aging
melatonin
microRNAs
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
27 Mar 2021
27 Mar 2021
Historique:
received:
27
02
2021
revised:
19
03
2021
accepted:
24
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
Muscular aging is a complex process and underlying physiological mechanisms are not fully clear. In recent years, the participation of the NF-kB pathway and the NLRP3 inflammasome in the chronic inflammation process that accompanies the skeletal muscle's aging has been confirmed. microRNAs (miRs) form part of a gene regulatory machinery, and they control numerous biological processes including inflammatory pathways. In this work, we studied the expression of four miRs; three of them are considered as inflammatory-related miRs (miR-21, miR-146a, and miR-223), and miR-483, which is related to the regulation of melatonin synthesis, among other targets. To investigate the changes of miRs expression in muscle along aging, the impact of inflammation, and the role of melatonin in aged skeletal muscle, we used the gastrocnemius muscle of wild type (WT) and NLRP3-knockout (NLRP3
Identifiants
pubmed: 33801675
pii: antiox10040524
doi: 10.3390/antiox10040524
pmc: PMC8066875
pii:
doi:
Types de publication
Journal Article
Langues
eng
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