Combined COX-2/PPARγ Expression as Independent Negative Prognosticator for Vulvar Cancer Patients.
COX-2
PPARγ
survival
vulvar cancer
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
10 Mar 2021
10 Mar 2021
Historique:
received:
07
12
2020
revised:
04
03
2021
accepted:
04
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
Vulvar cancer incidence numbers have been rising steadily over the past decades. Especially the number of young patients with vulvar cancer increased recently. Therefore, the need to identify new prognostic factors for vulvar carcinoma is more apparent. Cyclooxygenase-2 (COX-2) has long been an object of scientific interest in the context of carcinogenesis. This enzyme is involved in prostaglandin synthesis and the latter binds to nuclear receptors like PPARγ. Therefore, the aim of this study was to investigate COX-2- and PPARγ- expression in tissues of vulvar carcinomas and to analyze their relevance as prognostic factors. The cytoplasmatic expression of COX-2 as well as PPARγ is associated with a significantly reduced survival, whereas nuclear expression of PPARγ results in a better survival. Especially the combined expression of both COX-2 and PPARγ in the cytoplasm is an independent negative prognosticator for vulvar cancer patients.
Identifiants
pubmed: 33802010
pii: diagnostics11030491
doi: 10.3390/diagnostics11030491
pmc: PMC8001561
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Dig Dis Sci. 2007 Sep;52(9):2305-11
pubmed: 17393321
J Cancer Surviv. 2016 Apr;10(2):261-70
pubmed: 26245979
Int J Gynecol Cancer. 2007 Jan-Feb;17(1):164-73
pubmed: 17291249
Cell. 1999 Apr 16;97(2):161-3
pubmed: 10219237
Clin Cancer Res. 2001 May;7(5):1410-8
pubmed: 11350912
Cell. 1995 Nov 3;83(3):493-501
pubmed: 8521479
Br J Cancer. 2004 Jan 26;90(2):423-9
pubmed: 14735188
Nat Med. 1998 Sep;4(9):1046-52
pubmed: 9734398
Am J Surg Pathol. 2015 Aug;39(8):1045-53
pubmed: 26171917
J Biol Chem. 1995 Jul 7;270(27):16114-21
pubmed: 7608174
FEBS Lett. 2002 Aug 14;525(1-3):43-7
pubmed: 12163159
Cell. 1992 Mar 6;68(5):879-87
pubmed: 1312391
Int J Gynecol Pathol. 2007 Apr;26(2):188-93
pubmed: 17413988
J Transl Med. 2020 Feb 21;18(1):94
pubmed: 32085795
FASEB J. 1993 Aug;7(11):1045-51
pubmed: 8370474
Cell Cycle. 2007 Jul 1;6(13):1539-48
pubmed: 17611413
Prostaglandins Other Lipid Mediat. 2000 Jun;62(1):23-32
pubmed: 10936413
Mol Cell. 1999 Jun;3(6):799-804
pubmed: 10394368
Mol Cell Endocrinol. 1997 Apr 25;129(1):17-26
pubmed: 9175625
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3951-6
pubmed: 10097144
Gut. 2006 Jan;55(1):115-22
pubmed: 16118353
Cancer Res. 1995 Sep 1;55(17):3785-9
pubmed: 7641194
Mol Endocrinol. 1999 Mar;13(3):366-75
pubmed: 10076994
Int J Oncol. 1999 Nov;15(5):967-73
pubmed: 10536181
Nat Immunol. 2004 Jan;5(1):104-12
pubmed: 14691478
Eur J Cancer Prev. 1995 Dec;4(6):491-5
pubmed: 8580785
Neoplasia. 2006 Oct;8(10):851-61
pubmed: 17032502
Curr Med Chem. 2019;26(18):3225-3241
pubmed: 29756563
Nature. 1992 Aug 27;358(6389):771-4
pubmed: 1324435
J Biol Chem. 2000 Jun 16;275(24):18527-33
pubmed: 10748014
Endocrinology. 1994 Aug;135(2):798-800
pubmed: 8033830
Cancer Res. 1998 Nov 15;58(22):4997-5001
pubmed: 9823297
Histopathology. 2011 Nov;59(5):909-17
pubmed: 22092402
J Lab Clin Med. 1996 Sep;128(3):242-5
pubmed: 8783630
BMC Cancer. 2014 Jun 20;14:458
pubmed: 24950702
J Natl Cancer Inst. 2015 Jan 24;107(3):
pubmed: 25618900
J Clin Pathol. 2006 Jun;59(6):618-23
pubmed: 16731602
Br J Cancer. 2003 May 19;88(10):1598-604
pubmed: 12771929
J Low Genit Tract Dis. 2007 Apr;11(2):80-5
pubmed: 17415111
Cancer Res. 1996 Oct 1;56(19):4424-9
pubmed: 8813136
J Clin Oncol. 2005 Jan 10;23(2):254-66
pubmed: 15637389
Lancet. 2010 Nov 20;376(9754):1741-50
pubmed: 20970847
Biochem Biophys Res Commun. 2004 Sep 24;322(3):1066-72
pubmed: 15336573
Prostate. 2011 Jun 1;71(8):813-23
pubmed: 21456064
Exp Cell Res. 1980 Feb;125(2):490-3
pubmed: 6986277
J Lipid Res. 1998 Dec;39(12):2329-38
pubmed: 9831621
Nat Med. 1998 Sep;4(9):1058-61
pubmed: 9734400
Anticancer Res. 2010 Jul;30(7):3023-30
pubmed: 20683050
Cancer Res. 1999 Mar 1;59(5):987-90
pubmed: 10070951
Ann Surg Oncol. 2013 Jan;20(1):31-9
pubmed: 22878614
J Cancer Res Clin Oncol. 2020 Mar;146(3):569-577
pubmed: 32025868
FASEB J. 1998 Sep;12(12):1063-73
pubmed: 9737710
Breast Cancer Res Treat. 2015 Apr;150(3):511-22
pubmed: 25794775
FEBS Lett. 1993 Apr 26;321(2-3):209-14
pubmed: 8477853
Cancer Res. 2000 Mar 1;60(5):1306-11
pubmed: 10728691
Am J Obstet Gynecol. 1973 Mar 1;115(5):677-86
pubmed: 4739435
Cancer Res. 1997 Apr 1;57(7):1276-80
pubmed: 9102213
Cell. 1989 Jun 30;57(7):1147-54
pubmed: 2736623
Proc Natl Acad Sci U S A. 1996 May 14;93(10):4845-50
pubmed: 8643491
Lancet Oncol. 2007 Oct;8(10):912-20
pubmed: 17881290
Breast Cancer Res. 2007;9(4):210
pubmed: 17640394
Mol Pharmacol. 1992 Feb;41(2):393-8
pubmed: 1538716
J Biol Chem. 2004 Nov 5;279(45):46384-92
pubmed: 15319438
Am J Pathol. 2002 Mar;160(3):893-903
pubmed: 11891188
Best Pract Res Clin Obstet Gynaecol. 2018 Feb;47:42-58
pubmed: 28986092
Gynecol Oncol. 2019 Jan;152(1):208-217
pubmed: 30415992
JAMA. 1999 Oct 6;282(13):1254-7
pubmed: 10517428
J Transl Med. 2012 Jul 28;10:150
pubmed: 22839358
Melanoma Res. 2009 Feb;19(1):8-16
pubmed: 19430402
Sci Rep. 2018 Jan 10;8(1):327
pubmed: 29321644
Ann N Y Acad Sci. 2007 Jan;1095:143-53
pubmed: 17404027
Nat Med. 1998 Sep;4(9):1053-7
pubmed: 9734399
Cancer Res. 2006 Jul 1;66(13):6657-64
pubmed: 16818639
Cancer Res. 2002 May 1;62(9):2516-21
pubmed: 11980643
Nature. 1990 Oct 18;347(6294):645-50
pubmed: 2129546
J Lab Clin Med. 1993 Nov;122(5):518-23
pubmed: 8228569
Int J Cancer. 2017 Dec 1;141(11):2174-2186
pubmed: 28730615
Molecules. 2019 Dec 24;25(1):
pubmed: 31878261
Gastroenterology. 2009 Apr;136(4):1242-50
pubmed: 19186181
Gynecol Oncol. 2019 Sep;154(3):565-570
pubmed: 31227222
Am J Physiol. 1992 Jul;263(1 Pt 2):F97-102
pubmed: 1636747
Lung Cancer. 2002 Jun;36(3):249-55
pubmed: 12009233
Nature. 2008 Jul 24;454(7203):470-7
pubmed: 18650918
FEBS Lett. 1999 Jul 16;455(1-2):135-9
pubmed: 10428487
Am J Obstet Gynecol. 1990 Jun;162(6):1633-4
pubmed: 2163194
Br J Cancer. 2005 Jan 17;92(1):113-9
pubmed: 15583697
FEBS Lett. 1990 Sep 17;270(1-2):15-8
pubmed: 2226777
Nat Rev Cancer. 2002 May;2(5):342-50
pubmed: 12044010
J Natl Cancer Inst. 1997 Oct 15;89(20):1516-23
pubmed: 9337348
Mol Cell Biol. 2007 Feb;27(3):803-17
pubmed: 17101779
Cancer Res. 2003 Feb 1;63(3):728-34
pubmed: 12566320
Semin Oncol. 2004 Feb;31(1 Suppl 3):64-73
pubmed: 15052544
Arzneimittelforschung. 1990 Jan;40(1):37-42
pubmed: 2339998
Arch Biochem Biophys. 1993 Jul;304(1):226-34
pubmed: 8323287
Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8806-11
pubmed: 9671760
J Biol Chem. 1998 Jan 23;273(4):1855-8
pubmed: 9442016
Gynecol Oncol. 2012 Jul;126(1):87-92
pubmed: 22516660
Carcinogenesis. 2004 Sep;25(9):1747-55
pubmed: 15073042
Clin Cancer Res. 2003 May;9(5):1741-9
pubmed: 12738729
Cancer. 1995 Nov 15;76(10):1786-9
pubmed: 8625048
Gynecol Oncol. 1991 Dec;43(3):275-80
pubmed: 1661264
Pathologe. 1987 May;8(3):138-40
pubmed: 3303008
Br J Pharmacol. 2011 Aug;163(7):1533-49
pubmed: 21501147
J Biol Chem. 2001 Apr 6;276(14):11237-45
pubmed: 11152480
Neoplasia. 1999 Oct;1(4):330-9
pubmed: 10935488
Biochem Biophys Res Commun. 2001 Sep 21;287(2):522-9
pubmed: 11554760