Inhibitors of Cyclin-Dependent Kinases: Types and Their Mechanism of Action.
CDK inhibitors
CDKs
cancer
cell cycle
cyclin-dependent kinase inhibitors
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Mar 2021
10 Mar 2021
Historique:
received:
12
02
2021
revised:
03
03
2021
accepted:
05
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
23
4
2021
Statut:
epublish
Résumé
Recent studies on cyclin-dependent kinase (CDK) inhibitors have revealed that small molecule drugs have become very attractive for the treatment of cancer and neurodegenerative disorders. Most CDK inhibitors have been developed to target the ATP binding pocket. However, CDK kinases possess a very similar catalytic domain and three-dimensional structure. These features make it difficult to achieve required selectivity. Therefore, inhibitors which bind outside the ATP binding site present a great interest in the biomedical field, both from the fundamental point of view and for the wide range of their potential applications. This review tries to explain whether the ATP competitive inhibitors are still an option for future research, and highlights alternative approaches to discover more selective and potent small molecule inhibitors.
Identifiants
pubmed: 33802080
pii: ijms22062806
doi: 10.3390/ijms22062806
pmc: PMC8001317
pii:
doi:
Substances chimiques
Neoplasm Proteins
0
Protein Kinase Inhibitors
0
Cyclin-Dependent Kinases
EC 2.7.11.22
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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