Diagnostic and Prognostic Value of CEA and CA19-9 in Colorectal Cancer.
CA19-9
CEA
biomarkers
carbohydrate antigen 19-9
carcinoembryonic antigen
colorectal cancer
prognosis
survival
tumor markers
Journal
Diseases (Basel, Switzerland)
ISSN: 2079-9721
Titre abrégé: Diseases
Pays: Switzerland
ID NLM: 101636232
Informations de publication
Date de publication:
17 Mar 2021
17 Mar 2021
Historique:
received:
11
02
2021
revised:
07
03
2021
accepted:
10
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
Colorectal cancer (CRC) is the third most common cancer worldwide. A diagnosis at early stages with enhanced screening methods is vital as metastases and recurrences increase mortality. The aim of this study was to analyze the tumor markers CEA and CA19-9 combined in correlation with diagnostics and prognosis. Therefore, 1487 patients with CRC who were diagnosed and treated between 2000 and 2015 at the University Hospital Ulm, Germany, were retrospectively evaluated. Overall and recurrence-free survival was analyzed in association with preoperative CEA and CA19-9 separately and combined and a multivariate analysis was performed. The 5-year overall survival was significantly shorter in patients with a CEA or CA19-9 level ≥200 compared to patients with an increased, but <200, or normal level (CEA: 69%/44%/7%; CA19-9: 66%/38%/8%). Patients with both tumor markers increased also showed a remarkably shorter 5-year survival rate (CEA+/CA19-9+: 23%). The multivariate analysis emphasizes these results (
Identifiants
pubmed: 33802962
pii: diseases9010021
doi: 10.3390/diseases9010021
pmc: PMC8006010
pii:
doi:
Types de publication
Journal Article
Langues
eng
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