Endocannabinoid System as Therapeutic Target of PTSD: A Systematic Review.

CBD PTSD PTSD treatment THC cannabidiol endocannabinoids nabilone systematic review Δ9-tetrahydrocannabinol

Journal

Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444

Informations de publication

Date de publication:
09 Mar 2021
Historique:
received: 29 01 2021
revised: 20 02 2021
accepted: 05 03 2021
entrez: 3 4 2021
pubmed: 4 4 2021
medline: 4 4 2021
Statut: epublish

Résumé

Post-Traumatic Stress Disorder (PTSD) is a complex disorder involving dysregulation of stress-related hormones and neurotransmitter systems. Research focused on the endocannabinoid system (eCBS) for anxiety and stress regulation, cognitive and emotional responses modulation and aversive memories extinction, leading to the hypothesis that it could represent a possible alternative treatment target for PTSD. In this systematic review, we summarize evidence about the efficacy and safety of medicinal cannabidiol (CBD), Δ

Identifiants

pubmed: 33803374
pii: life11030214
doi: 10.3390/life11030214
pmc: PMC8000573
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

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Auteurs

Luca Steardo (L)

Psychiatric Unit, Department of Health Sciences, University Magna Graecia of Catanzaro, Viale Tommaso Campanella, 115, 88100 Catanzaro, Italy.

Elvira Anna Carbone (EA)

Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Viale Tommaso Campanella, 115, 88100 Catanzaro, Italy.

Giulia Menculini (G)

Department of Psychiatry, University of Perugia, Piazzale Lucio Severi, 1, 06132 Perugia, Italy.

Patrizia Moretti (P)

Department of Psychiatry, University of Perugia, Piazzale Lucio Severi, 1, 06132 Perugia, Italy.

Luca Steardo (L)

Department of Physiology and Pharmacology, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.
Department of Psychiatry, Giustino Fortunato University, 12, 82100 Benevento, Italy.

Alfonso Tortorella (A)

Department of Psychiatry, University of Perugia, Piazzale Lucio Severi, 1, 06132 Perugia, Italy.

Classifications MeSH