Ex-Vivo Pharmacological Defatting of the Liver: A Review.
defatting
ex-vivo perfusion
liver perfusion
liver transplantation
normothermic machine perfusion
steatosis
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
18 Mar 2021
18 Mar 2021
Historique:
received:
01
02
2021
revised:
12
03
2021
accepted:
15
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
The ongoing organ shortage has forced transplant teams to develop alternate sources of liver grafts. In this setting, ex-situ machine perfusion has rapidly developed as a promising tool to assess viability and improve the function of organs from extended criteria donors, including fatty liver grafts. In particular, normothermic machine perfusion represents a powerful tool to test a liver in full 37 °C metabolism and add pharmacological corrections whenever needed. In this context, many pharmacological agents and therapeutics have been tested to induce liver defatting on normothermic machine perfusion with promising results even on human organs. This systematic review makes a comprehensive synthesis on existing pharmacological therapies for liver defatting, with special focus on normothermic liver machine perfusion as an experimental ex-vivo translational model.
Identifiants
pubmed: 33803539
pii: jcm10061253
doi: 10.3390/jcm10061253
pmc: PMC8002874
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
J Surg Res. 2005 Apr;124(2):160-8
pubmed: 15820243
J Clin Med. 2020 Apr 07;9(4):
pubmed: 32272760
Transplantation. 2020 Sep;104(9):1792-1803
pubmed: 32371846
Nat Biotechnol. 2020 Feb;38(2):189-198
pubmed: 31932726
PLoS One. 2020 Jan 24;15(1):e0228011
pubmed: 31978172
World J Transplant. 2020 Jan 18;10(1):1-14
pubmed: 32110510
Am J Transplant. 2018 Oct;18(10):2384-2399
pubmed: 29947472
Hepatology. 1991 Jun;13(6):1126-30
pubmed: 1646760
Dis Model Mech. 2020 Apr 29;13(4):
pubmed: 32094147
J Hepatol. 2010 Aug;53(2):372-84
pubmed: 20494470
Liver Transpl. 2016 Apr;22(4):459-67
pubmed: 26714616
Metabolites. 2016 Jan 04;6(1):
pubmed: 26742084
Mod Pathol. 2007 Feb;20 Suppl 1:S40-8
pubmed: 17486051
PLoS One. 2018 Jul 25;13(7):e0201419
pubmed: 30044872
Liver Transpl. 2016 Jul;22(7):979-93
pubmed: 27027254
HPB (Oxford). 2020 Jun;22(6):927-933
pubmed: 32409166
Transplantation. 2011 Aug 15;92(3):289-95
pubmed: 21681143
Am J Transplant. 2004 Sep;4(9):1440-7
pubmed: 15307831
Biochem J. 1989 Nov 15;264(1):93-100
pubmed: 2557835
Transplant Proc. 2013 Nov;45(9):3209-13
pubmed: 24182786
Am J Transplant. 2017 Apr;17(4):970-978
pubmed: 27805315
Biochem J. 1992 Jun 1;284 ( Pt 2):457-62
pubmed: 1599431
Liver Transpl. 2014 Aug;20(8):1000-11
pubmed: 24802973
J Hepatol. 2012 Sep;57(3):675-88
pubmed: 22609307
Science. 2011 Jun 24;332(6037):1519-23
pubmed: 21700865
J Hepatol. 2020 Apr;72(4):627-635
pubmed: 31760070
Liver Transpl. 2019 Jan;25(1):140-151
pubmed: 30561891
J Gastroenterol Hepatol. 2012 Mar;27(3):540-6
pubmed: 21777274
Biomech Model Mechanobiol. 2017 Aug;16(4):1095-1102
pubmed: 28220319
Metab Eng. 2009 Jul-Sep;11(4-5):274-83
pubmed: 19508897
Transplantation. 1999 Sep 27;68(6):780-4
pubmed: 10515377
Liver Transpl. 2010 Jul;16(7):874-84
pubmed: 20583086
J Clin Epidemiol. 2009 Oct;62(10):1006-12
pubmed: 19631508
Liver Transpl. 2019 Jul;25(7):1007-1022
pubmed: 30821045
Biochem J. 1970 Sep;119(3):525-33
pubmed: 5500312
J Surg Res. 2009 Mar;152(1):54-60
pubmed: 18599084