Antioxidant Therapeutics in Parkinson's Disease: Current Challenges and Opportunities.
Parkinson’s disease
antioxidants
clinical trials
oxidative stress
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
15 Mar 2021
15 Mar 2021
Historique:
received:
29
01
2021
revised:
08
03
2021
accepted:
11
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
Oxidative stress is considered one of the pathological mechanisms that cause Parkinson's disease (PD), which has led to the investigation of several antioxidants molecules as a potential therapeutic treatment against the disease. Although preclinical studies have demonstrated the efficacy of these compounds to maintain neuronal survival and activity in PD models, these results have not been reflected in clinical trials, antioxidants have not been able to act as disease modifiers in terms of clinical symptoms. Translational medicine currently faces the challenge of redesigning clinical trials to standardize criteria when testing molecules to reduce responses' variability. Herein, we discuss current challenges and opportunities regarding several non-enzymatic antioxidants' therapeutic molecules for PD patients' potential treatment.
Identifiants
pubmed: 33803945
pii: antiox10030453
doi: 10.3390/antiox10030453
pmc: PMC7998929
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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