Epigenetic Changes in Neoplastic Mast Cells and Potential Impact in Mastocytosis.
DNA (Cytosine-5-)-Methyltransferases
/ genetics
DNA Methyltransferase 3A
DNA-Binding Proteins
/ genetics
Dioxygenases
Epigenesis, Genetic
/ genetics
Hematologic Neoplasms
/ genetics
Humans
Mast Cells
/ pathology
Mastocytosis, Systemic
/ genetics
Mutation
/ genetics
Proto-Oncogene Proteins
/ genetics
Repressor Proteins
/ genetics
DNA methylation
DNMT3A
TET2
demethylating agents
epigenetics
mastocytosis
microRNA
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Mar 2021
15 Mar 2021
Historique:
received:
18
02
2021
revised:
10
03
2021
accepted:
12
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Systemic mastocytosis (SM) is a hematologic neoplasm with abnormal accumulation of mast cells in various organ systems such as the bone marrow, other visceral organs and skin. So far, only little is known about epigenetic changes contributing to the pathogenesis of SM. In the current article, we provide an overview of epigenetic changes that may occur and be relevant to mastocytosis, including mutations in genes involved in epigenetic processes, such as
Identifiants
pubmed: 33803981
pii: ijms22062964
doi: 10.3390/ijms22062964
pmc: PMC7999363
pii:
doi:
Substances chimiques
ASXL1 protein, human
0
DNA-Binding Proteins
0
DNMT3A protein, human
0
Proto-Oncogene Proteins
0
Repressor Proteins
0
Dioxygenases
EC 1.13.11.-
TET2 protein, human
EC 1.13.11.-
DNA (Cytosine-5-)-Methyltransferases
EC 2.1.1.37
DNA Methyltransferase 3A
EC 2.1.1.37
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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