Prognostic Cancer Gene Expression Signatures: Current Status and Challenges.
breast cancer
colorectal cancer
gene expression signature
hepatocellular carcinoma
prognostic
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
15 03 2021
15 03 2021
Historique:
received:
01
02
2021
revised:
05
03
2021
accepted:
08
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
20
11
2021
Statut:
epublish
Résumé
Current staging systems of cancer are mainly based on the anatomical extent of disease. They need refinement by biological parameters to improve stratification of patients for tumor therapy or surveillance strategies. Thanks to developments in genomic, transcriptomic, and big-data technologies, we are now able to explore molecular characteristics of tumors in detail and determine their clinical relevance. This has led to numerous prognostic and predictive gene expression signatures that have the potential to establish a classification of tumor subgroups by biological determinants. However, only a few gene signatures have reached the stage of clinical implementation so far. In this review article, we summarize the current status, and present and future challenges of prognostic gene signatures in three relevant cancer entities: breast cancer, colorectal cancer, and hepatocellular carcinoma.
Identifiants
pubmed: 33804045
pii: cells10030648
doi: 10.3390/cells10030648
pmc: PMC8000474
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Références
J Clin Oncol. 2011 Jan 1;29(1):17-24
pubmed: 21098318
J Clin Oncol. 2010 Apr 10;28(11):1829-34
pubmed: 20212256
Nat Med. 2013 May;19(5):614-8
pubmed: 23584090
BMC Cancer. 2010 Dec 23;10:691
pubmed: 21176237
Nat Med. 2013 May;19(5):619-25
pubmed: 23584089
Gut. 2012 Nov;61(11):1560-7
pubmed: 22213796
Int J Cancer. 2013 Aug 15;133(4):929-36
pubmed: 23371464
Oncotarget. 2017 Jul 25;8(30):48948-48958
pubmed: 28430663
Microarrays (Basel). 2013 Aug 29;2(3):243-64
pubmed: 27605191
JAMA Oncol. 2018 Apr 1;4(4):545-553
pubmed: 29450494
N Engl J Med. 2004 Dec 30;351(27):2817-26
pubmed: 15591335
Bioinformatics. 2015 Jan 15;31(2):216-24
pubmed: 25236463
BMC Med Genomics. 2012 Dec 31;5:66
pubmed: 23272949
BMC Cancer. 2012 Jun 19;12:260
pubmed: 22712570
Hepatology. 2004 Sep;40(3):667-76
pubmed: 15349906
Cell Death Differ. 2018 Mar;25(3):616-633
pubmed: 29305587
PLoS Med. 2013;10(5):e1001453
pubmed: 23700391
Clin Cancer Res. 2012 Nov 1;18(21):6001-10
pubmed: 22991413
Nat Med. 2015 Nov;21(11):1350-6
pubmed: 26457759
Nat Med. 2006 Apr;12(4):410-6
pubmed: 16532004
Hepatology. 2020 Jan;71(1):164-182
pubmed: 31206197
Eur J Cancer. 2020 Sep;137:193-203
pubmed: 32795875
Mod Pathol. 2020 Nov;33(11):2208-2220
pubmed: 32404959
Nat Rev Clin Oncol. 2017 Apr;14(4):235-246
pubmed: 27922044
Oncotarget. 2018 Apr 10;9(27):18698-18711
pubmed: 29721154
J Clin Oncol. 2011 Dec 10;29(35):4611-9
pubmed: 22067390
Clin Cancer Res. 2021 Jan 1;27(1):311-319
pubmed: 33109739
Hepatology. 2007 Jan;45(1):42-52
pubmed: 17187432
Nature. 2002 Jan 31;415(6871):530-6
pubmed: 11823860
Nat Med. 2003 Apr;9(4):416-23
pubmed: 12640447
N Engl J Med. 2015 Jun 25;372(26):2509-20
pubmed: 26028255
J Clin Oncol. 2016 Sep 1;34(25):3047-53
pubmed: 27432924
J Clin Oncol. 2019 Aug 1;37(22):1876-1885
pubmed: 31042420
J Hepatol. 2004 Aug;41(2):284-91
pubmed: 15288478
Ann Oncol. 2018 Nov 1;29(11):2240-2246
pubmed: 30247524
N Engl J Med. 2004 Apr 15;350(16):1617-28
pubmed: 15084694
Int J Cancer. 2021 Apr 15;148(8):1948-1963
pubmed: 33186476
Gastroenterology. 2020 Apr;158(5):1313-1325
pubmed: 31972239
J Clin Oncol. 2019 Aug 1;37(22):1956-1964
pubmed: 31150316
Br J Cancer. 2013 Dec 10;109(12):2959-64
pubmed: 24157828
J Hepatol. 2019 Sep;71(3):616-630
pubmed: 31195064
Cell Death Dis. 2020 Nov 30;11(11):1020
pubmed: 33257690
Gastroenterology. 2013 Jul;145(1):176-187
pubmed: 23567350
J Cell Physiol. 2020 Dec;235(12):9304-9316
pubmed: 32330311
J Cell Physiol. 2019 Nov;234(11):20859-20868
pubmed: 30997686
Cancer. 2012 Nov 1;118(21):5234-44
pubmed: 22605513
J Mol Med (Berl). 2019 Jun;97(6):879-888
pubmed: 31001651
PLoS One. 2016 Jun 16;11(6):e0157368
pubmed: 27310713
Clin Cancer Res. 2015 Apr 1;21(7):1688-98
pubmed: 25208879
Future Sci OA. 2017 Jun 05;3(3):FSO221
pubmed: 28884016
Cancer Res. 2010 Apr 15;70(8):3034-41
pubmed: 20395200
Lancet. 2003 Mar 15;361(9361):923-9
pubmed: 12648972
J Hepatol. 2020 Dec;73(6):1460-1469
pubmed: 32710922
N Engl J Med. 2004 Apr 29;350(18):1828-37
pubmed: 15115829
N Engl J Med. 2016 Aug 25;375(8):717-29
pubmed: 27557300
Ann Oncol. 2019 Nov 1;30(11):1796-1803
pubmed: 31868905
Clin Breast Cancer. 2020 Oct 24;:
pubmed: 33218957
Cancer. 2011 Oct 15;117(20):4623-32
pubmed: 21456008
J Natl Cancer Inst. 2009 Nov 4;101(21):1446-52
pubmed: 19815849
N Engl J Med. 2018 Jul 12;379(2):111-121
pubmed: 29860917
Cancer Res. 2009 Sep 15;69(18):7385-92
pubmed: 19723656
Breast Cancer Res. 2015 Jan 27;17:11
pubmed: 25848861
J Clin Oncol. 2019 Feb 10;37(5):423-438
pubmed: 30452337
Cell Stem Cell. 2011 May 6;8(5):511-24
pubmed: 21419747
J Clin Epidemiol. 2010 Sep;63(9):950-9
pubmed: 20579843
Nat Commun. 2018 Oct 5;9(1):4112
pubmed: 30291241
Gastroenterology. 2015 Apr;148(4):806-18.e10
pubmed: 25557953
Science. 1995 Oct 20;270(5235):467-70
pubmed: 7569999
CA Cancer J Clin. 2017 Jul 8;67(4):290-303
pubmed: 28294295
Ann Oncol. 2019 Nov 1;30(11):1776-1783
pubmed: 31504126
Ann Oncol. 2020 Oct;31(10):1291-1305
pubmed: 32702383
Gastroenterology. 2015 Oct;149(5):1226-1239.e4
pubmed: 26099527
Cancer Res. 2010 Dec 15;70(24):10202-12
pubmed: 21159642
Ann Oncol. 2019 Oct 1;30(10):1622-1629
pubmed: 31504112
J Clin Oncol. 2009 Mar 10;27(8):1160-7
pubmed: 19204204
J Hepatol. 2021 Mar;74(3):613-626
pubmed: 33038431
Oncologist. 2015 Feb;20(2):127-33
pubmed: 25561511
Hepatology. 2015 Jun;61(6):1945-56
pubmed: 25645722
J Pathol. 2013 Sep;231(1):63-76
pubmed: 23836465
Eur J Cancer. 2013 May;49(8):2000-9
pubmed: 23498875
Cancer Biol Med. 2018 Nov;15(4):425-433
pubmed: 30766752
N Engl J Med. 2008 Nov 6;359(19):1995-2004
pubmed: 18923165
Nat Commun. 2017 Oct 10;8(1):839
pubmed: 29018224
JAMA Oncol. 2016 Sep 1;2(9):1162-9
pubmed: 27270348
Ann Oncol. 2019 Jul 1;30(7):1044-1050
pubmed: 31131397
Gut. 2019 Jun;68(6):1065-1075
pubmed: 30108162
Breast Care (Basel). 2019 Aug;14(4):224-245
pubmed: 31558897
Cancers (Basel). 2020 Jan 30;12(2):
pubmed: 32019056
Cancer Cell. 2006 Aug;10(2):99-111
pubmed: 16904609
Science. 1999 Oct 15;286(5439):531-7
pubmed: 10521349
J Natl Cancer Inst. 2006 Sep 6;98(17):1183-92
pubmed: 16954471
Nat Commun. 2020 Sep 1;11(1):4383
pubmed: 32873799
Semin Oncol. 2012 Aug;39(4):473-85
pubmed: 22846864
Lancet Oncol. 2019 May;20(5):e274-e283
pubmed: 31044725
Ann Oncol. 2014 Feb;25(2):339-45
pubmed: 24347518
N Engl J Med. 2002 Dec 19;347(25):1999-2009
pubmed: 12490681
Clin Cancer Res. 2018 Feb 15;24(4):794-806
pubmed: 29242316
J Cell Physiol. 2020 Sep;235(9):6103-6112
pubmed: 31975381
Ann Oncol. 2019 Aug 1;30(8):1194-1220
pubmed: 31161190
Ann Surg. 2013 Jun;257(6):1053-8
pubmed: 23295318
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
J Clin Oncol. 2019 Dec 20;37(36):3484-3492
pubmed: 31657982
Lancet Oncol. 2010 Jan;11(1):55-65
pubmed: 20005174
J Hepatol. 2012 Apr;56(4):990-2
pubmed: 22173158
N Engl J Med. 2004 Apr 15;350(16):1605-16
pubmed: 15084693
Clin Cancer Res. 2008 Apr 1;14(7):2056-64
pubmed: 18381945
J Natl Cancer Inst. 2013 Jul 17;105(14):1036-42
pubmed: 23812955
Clin Cancer Res. 2008 May 1;14(9):2601-8
pubmed: 18451222
J Clin Oncol. 2011 Dec 10;29(35):4620-6
pubmed: 22067406
Nat Rev Cancer. 2017 Feb;17(2):79-92
pubmed: 28050011
J Clin Invest. 2011 Jul;121(7):2750-67
pubmed: 21633166
Oncol Lett. 2020 Jan;19(1):301-308
pubmed: 31897142