The Glycolytic Pathway as a Target for Novel Onco-Immunology Therapies in Pancreatic Cancer.
glycolysis
immunotherapies
pancreatic cancer
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
15 Mar 2021
15 Mar 2021
Historique:
received:
29
01
2021
revised:
02
03
2021
accepted:
11
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
8
5
2021
Statut:
epublish
Résumé
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal forms of human cancer, characterized by unrestrained progression, invasiveness and treatment resistance. To date, there are limited curative options, with surgical resection as the only effective strategy, hence the urgent need to discover novel therapies. A platform of onco-immunology targets is represented by molecules that play a role in the reprogrammed cellular metabolism as one hallmark of cancer. Due to the hypoxic tumor microenvironment (TME), PDA cells display an altered glucose metabolism-resulting in its increased uptake-and a higher glycolytic rate, which leads to lactate accumulation and them acting as fuel for cancer cells. The consequent acidification of the TME results in immunosuppression, which impairs the antitumor immunity. This review analyzes the genetic background and the emerging glycolytic enzymes that are involved in tumor progression, development and metastasis, and how this represents feasible therapeutic targets to counteract PDA. In particular, as the overexpressed or mutated glycolytic enzymes stimulate both humoral and cellular immune responses, we will discuss their possible exploitation as immunological targets in anti-PDA therapeutic strategies.
Identifiants
pubmed: 33804240
pii: molecules26061642
doi: 10.3390/molecules26061642
pmc: PMC7998946
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 12182
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 19931
Organisme : University of Turin Progetti Ateneo 2014 Compagnia di San Paolo
ID : PC-METAIMMUN-OTHER
Organisme : University of Turin Progetti Ateneo 2014 Compagnia di San Paolo
ID : PANTHER
Organisme : Bando CRT Città della Salute e della Scienza di Torino
ID : 2019.1887
Organisme : Fondazione Ricerca Molinette Onlus
ID : Fundus CD38
Organisme : Fondazione Ricerca Molinette Onlus
ID : Associazione Ursula e Giorgio Cytron
Organisme : Fondazione Nastro Viola
ID : 2020
Organisme : Fondazione Nadia Valsecchi
ID : 2020
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