Endothelial Glycocalyx as a Regulator of Fibrotic Processes.
Blood Proteins
/ chemistry
Capillary Permeability
/ genetics
Endothelium
/ chemistry
Fibrosis
/ genetics
Glucuronidase
/ adverse effects
Glycocalyx
/ chemistry
Glycosaminoglycans
/ chemistry
Humans
Matrix Metalloproteinases
/ adverse effects
Mechanotransduction, Cellular
/ genetics
Proteoglycans
/ chemistry
Reactive Oxygen Species
/ adverse effects
endothelium
fibrosis
glycocalyx
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Mar 2021
15 Mar 2021
Historique:
received:
01
02
2021
revised:
02
03
2021
accepted:
11
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
24
4
2021
Statut:
epublish
Résumé
The endothelial glycocalyx, the gel layer covering the endothelium, is composed of glycosaminoglycans, proteoglycans, and adsorbed plasma proteins. This structure modulates vessels' mechanotransduction, vascular permeability, and leukocyte adhesion. Thus, it regulates several physiological and pathological events. In the present review, we described the mechanisms that disturb glycocalyx stability such as reactive oxygen species, matrix metalloproteinases, and heparanase. We then focused our attention on the role of glycocalyx degradation in the induction of profibrotic events and on the possible pharmacological strategies to preserve this delicate structure.
Identifiants
pubmed: 33804258
pii: ijms22062996
doi: 10.3390/ijms22062996
pmc: PMC7999025
pii:
doi:
Substances chimiques
Blood Proteins
0
Glycosaminoglycans
0
Proteoglycans
0
Reactive Oxygen Species
0
heparanase
EC 3.2.1.-
Glucuronidase
EC 3.2.1.31
Matrix Metalloproteinases
EC 3.4.24.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Università degli Studi di Padova
ID : BIRD192859/19
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