Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer.
Carcinogenesis
/ genetics
Humans
Interleukin-13
/ genetics
Interleukin-13 Receptor alpha1 Subunit
/ genetics
Interleukin-13 Receptor alpha2 Subunit
/ genetics
Interleukin-4
/ genetics
Interleukin-4 Receptor alpha Subunit
/ genetics
Pancreatic Neoplasms
/ genetics
Receptors, Interleukin
/ genetics
Signal Transduction
/ genetics
cytokine
interleukin-13
interleukin-4
interleukin-4 receptor
pancreatic cancer
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Mar 2021
15 Mar 2021
Historique:
received:
15
02
2021
revised:
08
03
2021
accepted:
09
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
24
4
2021
Statut:
epublish
Résumé
Interleukin (IL)-4 and IL-13 are known as pleiotropic Th2 cytokines with a wide range of biological properties and functions especially in immune responses. In addition, increasing activities have also been determined in oncogenesis and tumor progression of several malignancies. It is now generally accepted that IL-4 and IL-13 can exert effects on epithelial tumor cells through corresponding receptors. Type II IL-4 receptor (IL-4Rα/IL-13Rα1), predominantly expressed in non-hematopoietic cells, is identified to be the main target for both IL-4 and IL-13 in tumors. Moreover, IL-13 can also signal by binding to the IL-13Rα2 receptor. Structural similarity due to the use of the same receptor complex generated in response to IL-4/IL-13 results in overlapping but also distinct signaling pathways and functions. The aim of this review was to summarize knowledge about IL-4 and IL-13 and their receptors in pancreatic cancer in order understand the implication of IL-4 and IL-13 and their receptors for pancreatic tumorigenesis and progression and for developing possible new diagnostic and therapeutic targets.
Identifiants
pubmed: 33804263
pii: ijms22062998
doi: 10.3390/ijms22062998
pmc: PMC8000536
pii:
doi:
Substances chimiques
IL4 protein, human
0
Interleukin-13
0
Interleukin-13 Receptor alpha1 Subunit
0
Interleukin-13 Receptor alpha2 Subunit
0
Interleukin-4 Receptor alpha Subunit
0
Receptors, Interleukin
0
Interleukin-4
207137-56-2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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