Fibrosis after Myocardial Infarction: An Overview on Cellular Processes, Molecular Pathways, Clinical Evaluation and Prognostic Value.
cardiac magnetic resonance
fibrosis
inflammation
molecular pathways
myocardial infarction
prognostic value
Journal
Medical sciences (Basel, Switzerland)
ISSN: 2076-3271
Titre abrégé: Med Sci (Basel)
Pays: Switzerland
ID NLM: 101629322
Informations de publication
Date de publication:
01 03 2021
01 03 2021
Historique:
received:
30
12
2020
revised:
17
02
2021
accepted:
22
02
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
The ischemic injury caused by myocardial infarction activates a complex healing process wherein a powerful inflammatory response and a reparative phase follow and balance each other. An intricate network of mediators finely orchestrate a large variety of cellular subtypes throughout molecular signaling pathways that determine the intensity and duration of each phase. At the end of this process, the necrotic tissue is replaced with a fibrotic scar whose quality strictly depends on the delicate balance resulting from the interaction between multiple actors involved in fibrogenesis. An inflammatory or reparative dysregulation, both in term of excess and deficiency, may cause ventricular dysfunction and life-threatening arrhythmias that heavily affect clinical outcome. This review discusses cellular process and molecular signaling pathways that determine fibrosis and the imaging technique that can characterize the clinical impact of this process in-vivo.
Identifiants
pubmed: 33804308
pii: medsci9010016
doi: 10.3390/medsci9010016
pmc: PMC7931027
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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