The Multifaceted Roles of EGFL7 in Cancer and Drug Resistance.
ECM
EGFL7
EGFR
EMT
FAK
KLF2
LOX
adhesion
angiocrine factor
angiogenesis
beta 3 integrin
cancer
drug resistance
endothelial cells
integrin
miR-126
migration
proliferation
protease
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
01 Mar 2021
01 Mar 2021
Historique:
received:
08
02
2021
revised:
20
02
2021
accepted:
22
02
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
Invasion of cancer cells into surrounding tissue and the vasculature is an important step for tumor progression and the establishment of distant metastasis. The extracellular matrix (ECM) is home to many biomolecules that support new vessel formation and cancer growth. Endothelial cells release growth factors such as epidermal growth factor-like protein-7 (EGFL7), which contributes to the formation of the tumor vasculature. The signaling axis formed by EGFL7 and one of its receptors, beta 3 integrin, has emerged as a key mediator in the regulation of tumor metastasis and drug resistance. Here we summarize recent studies on the role of the ECM-linked angiocrine factor EGFL7 in primary tumor growth, neoangiogenesis, tumor metastasis by enhancing epithelial-mesenchymal transition, alterations in ECM rigidity, and drug resistance. We discuss its role in cellular adhesion and migration, vascular leakiness, and the anti-cancer response and provide background on its transcriptional regulation. Finally, we discuss its potential as a drug target as an anti-cancer strategy.
Identifiants
pubmed: 33804387
pii: cancers13051014
doi: 10.3390/cancers13051014
pmc: PMC7957479
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 19K0885
Organisme : Japan Society for the Promotion of Science
ID : 18K08857
Organisme : Japan Society for the Promotion of Science
ID : 18K08657
Organisme : Uehara Memorial Foundation
ID : BH
Organisme : Okinaka Memorial Institute for Medical Research
ID : KH
Organisme : Thermo Scientific
ID : KH
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