Enhanced Skin Permeation of Estradiol by Dimethyl Sulfoxide Containing Transdermal Patches.

dimethyl sulfoxide enhanced skin permeation estradiol permeation recrystallization inhibition transdermal patch

Journal

Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003

Informations de publication

Date de publication:
01 Mar 2021
Historique:
received: 04 01 2021
revised: 24 02 2021
accepted: 24 02 2021
entrez: 3 4 2021
pubmed: 4 4 2021
medline: 4 4 2021
Statut: epublish

Résumé

Dimethyl sulfoxide is a well-known and widely used dermal penetration enhancer. Its incorporation in transdermal patches would be highly desirable; however, due to its volatility this is extremely challenging. Here, we report on the feasibility of a dimethyl sulfoxide (DMSO) containing transdermal system containing estradiol as a model compound. Transdermal patches were prepared from duro-tak

Identifiants

pubmed: 33804395
pii: pharmaceutics13030320
doi: 10.3390/pharmaceutics13030320
pmc: PMC7999216
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Anna Otterbach (A)

Department of Pharmaceutics, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Str. 3, 53121 Bonn, Germany.

Alf Lamprecht (A)

Department of Pharmaceutics, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Str. 3, 53121 Bonn, Germany.
PEPITE EA4267, University of Burgundy/Franche-Comté, 25000 Besançon, France.

Classifications MeSH