Emerging Medical Treatment for Hypertrophic Cardiomyopathy.
hypertrophic cardiomyopathy
left ventricular outflow tract obstruction
mavacamten
septal reduction therapy
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
01 Mar 2021
01 Mar 2021
Historique:
received:
04
02
2021
revised:
18
02
2021
accepted:
19
02
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
Hypertrophic cardiomyopathy (HCM) is a common myocardial disease characterized by otherwise unexplained left ventricular hypertrophy. The main cause of disabling symptoms in patients with HCM is left ventricular outflow tract (LVOT) obstruction. This phenomenon is multifactorial, determined both by anatomical and functional abnormalities: myocardial hypercontractility is believed to represent one of its major determinants. The anatomical anomalies are targeted by surgical interventions, whereas attenuating hypercontractility is the objective of old and new drugs including the novel class of allosteric myosin inhibitors. This review summarizes the current treatment modalities and discusses the emerging therapeutical opportunities focusing on the recently developed cardiac myosin ATPase inhibitors Mavacamten and CK-274. Novel surgical and interventional approaches are also discussed.
Identifiants
pubmed: 33804412
pii: jcm10050951
doi: 10.3390/jcm10050951
pmc: PMC7957690
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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