T and B Lymphocyte Transcriptional States Differentiate between Sensitized and Unsensitized Individuals in Alpha-Gal Syndrome.
Adolescent
Adult
Aged
Aged, 80 and over
Allergens
/ immunology
B-Lymphocytes
/ immunology
Case-Control Studies
Computational Biology
/ methods
Diagnosis, Differential
Female
Food Hypersensitivity
/ diagnosis
Gene Expression Profiling
Humans
Immunization
Immunoglobulin E
/ immunology
Killer Cells, Natural
/ immunology
Leukocytes, Mononuclear
/ immunology
Lymphocyte Activation
Male
Middle Aged
Red Meat
/ adverse effects
T-Lymphocytes
/ immunology
Transcription, Genetic
Young Adult
IgE
alpha-gal
alpha-gal syndrome
red meat allergy
tick
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Mar 2021
20 Mar 2021
Historique:
received:
22
01
2021
revised:
08
03
2021
accepted:
17
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
13
5
2021
Statut:
epublish
Résumé
The mechanisms of pathogenesis driving alpha-gal syndrome (AGS) are not fully understood. Differences in immune gene expression between AGS individuals and non-allergic controls may illuminate molecular pathways and targets critical for AGS development. We performed immune expression profiling with RNA from the peripheral blood mononuclear cells (PBMCs) of seven controls, 15 AGS participants, and two participants sensitized but not allergic to alpha-gal using the NanoString nCounter PanCancer immune profiling panel, which includes 770 genes from 14 different cell types. The top differentially expressed genes (DEG) between AGS subjects and controls included transcription factors regulating immune gene expression, such as the NFκB pathway (
Identifiants
pubmed: 33804792
pii: ijms22063185
doi: 10.3390/ijms22063185
pmc: PMC8003943
pii:
doi:
Substances chimiques
Allergens
0
Immunoglobulin E
37341-29-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI135049
Pays : United States
Organisme : NIAID NIH HHS
ID : K08 AI141691
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : K08AI141691
Organisme : American Academy of Allergy Asthma and Immunology
ID : 2020 American Academy of Allergy, Asthma, and Immunology (AAAAI) Foundation Career Development Award
Organisme : National Institute of Allergy and Infectious Diseases
ID : R01AI135049
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