Pharmacogenomics of Lithium Response in Bipolar Disorder.
Genome-Wide Association Study (GWAS)
bipolar disorder
lithium
personalized medicine
pharmacogenomics
predictive models
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
24 Mar 2021
24 Mar 2021
Historique:
received:
02
03
2021
revised:
19
03
2021
accepted:
21
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
Despite being the most widely studied mood stabilizer, researchers have not confirmed a mechanism for lithium's therapeutic efficacy in Bipolar Disorder (BD). Pharmacogenomic applications may be clinically useful in the future for identifying lithium-responsive patients and facilitating personalized treatment. Six genome-wide association studies (GWAS) reviewed here present evidence of genetic variations related to lithium responsivity and side effect expression. Variants were found on genes regulating the glutamate system, including GAD-like gene 1 (
Identifiants
pubmed: 33804842
pii: ph14040287
doi: 10.3390/ph14040287
pmc: PMC8063790
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NIMH NIH HHS
ID : K01 MH121580
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR003168
Pays : United States
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