Role of Angiogenesis in the Pathogenesis of NAFLD.
liver sinusoidal endothelial cells
non-alcoholic steatohepatitis
vascular endothelial growth factor
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
24 Mar 2021
24 Mar 2021
Historique:
received:
31
01
2021
revised:
15
03
2021
accepted:
17
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease, exposing to the risk of liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Angio-genesis is a complex process leading to the development of new vessels from pre-existing vessels. Angiogenesis is triggered by hypoxia and inflammation and is driven by the action of proangiogenic cytokines, mainly vascular endothelial growth factor (VEGF). In this review, we focus on liver angiogenesis associated with NAFLD and analyze the evidence of liver angiogenesis in animal models of NAFLD and in NAFLD patients. We also report the data explaining the role of angiogenesis in the progression of NAFLD and discuss the potential of targeting angiogenesis, notably VEGF, to treat NAFLD.
Identifiants
pubmed: 33804956
pii: jcm10071338
doi: 10.3390/jcm10071338
pmc: PMC8037441
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Fondation pour la Recherche Médicale
ID : EQU202003010517
Références
Aliment Pharmacol Ther. 2001 Oct;15(10):1667-72
pubmed: 11564008
Nat Rev Gastroenterol Hepatol. 2018 Jan;15(1):11-20
pubmed: 28930295
Endocrinol Diabetes Nutr. 2019 Aug - Sep;66(7):434-442
pubmed: 30833154
Nature. 2011 May 19;473(7347):298-307
pubmed: 21593862
Adv Biomed Res. 2015 May 06;4:79
pubmed: 26015905
Cell Tissue Res. 2016 Sep;365(3):583-9
pubmed: 27324023
Hepatology. 2002 May;35(5):1010-21
pubmed: 11981751
J Hepatol. 2019 Jun;70(6):1278-1291
pubmed: 30797053
Indian J Clin Biochem. 2011 Apr;26(2):202-9
pubmed: 22468051
Cells. 2019 Nov 11;8(11):
pubmed: 31718044
J Hepatol. 2017 Jan;66(1):212-227
pubmed: 27423426
Anat Rec (Hoboken). 2008 Jun;291(6):684-92
pubmed: 18484615
Hepatology. 2006 Oct;44(4):983-91
pubmed: 17006938
Hepatology. 2007 Dec;46(6):1919-26
pubmed: 17935226
Dig Dis Sci. 2018 Mar;63(3):563-576
pubmed: 29368124
Mol Med Rep. 2008 Jul-Aug;1(4):543-8
pubmed: 21479447
Cancer Sci. 2019 Feb;110(2):771-783
pubmed: 30520543
Int J Obes (Lond). 2017 Aug;41(8):1207-1213
pubmed: 28461687
Circ Res. 2017 May 12;120(10):1658-1673
pubmed: 28495996
JHEP Rep. 2019 Feb 23;1(1):30-43
pubmed: 32149275
Gut. 2003 Sep;52(9):1347-54
pubmed: 12912869
Mol Cell Endocrinol. 2013 Sep 25;378(1-2):29-40
pubmed: 22579612
Sci Signal. 2013 Oct 08;6(296):ra88
pubmed: 24106341
Nat Rev Endocrinol. 2018 Dec;15(1):21-32
pubmed: 30275460
J Pathol. 2012 Mar;226(4):588-97
pubmed: 21959987
Nature. 2019 Nov;575(7783):512-518
pubmed: 31597160
Cytokine. 2012 Aug;59(2):442-9
pubmed: 22658783
Biochim Biophys Acta Mol Basis Dis. 2019 May 1;1865(5):943-953
pubmed: 29990551
Liver Int. 2011 Feb;31(2):146-62
pubmed: 21073649
Mol Biol Rep. 2020 Mar;47(3):2279-2288
pubmed: 32040707
Hepatology. 2015 Mar;61(3):1041-55
pubmed: 25043701
Hepatology. 2011 Aug;54(2):573-85
pubmed: 21567441
Gut. 2016 May;65(5):861-9
pubmed: 25666192
Hepatol Res. 2006 Oct;36(2):124-9
pubmed: 16919500
Lab Invest. 2011 Feb;91(2):241-51
pubmed: 20921950
Gut. 2014 Dec;63(12):1960-1971
pubmed: 24561613
Hepatology. 2013 May;57(5):1793-805
pubmed: 23299577
Gastroenterology. 2008 Nov;135(5):1729-38
pubmed: 18823985
Nat Rev Gastroenterol Hepatol. 2014 Jun;11(6):350-61
pubmed: 24492276
Gastroenterology. 2014 May;146(5):1339-50.e1
pubmed: 24503129
Hepatology. 2019 Mar;69(3):1087-1104
pubmed: 30259536
J Pathol. 1996 Apr;178(4):363-6
pubmed: 8691311
PLoS One. 2013 Aug 30;8(8):e73492
pubmed: 24023685
Aliment Pharmacol Ther. 2018 Oct;48(7):696-703
pubmed: 30136293
J Gastroenterol. 2013 Apr;48(4):491-503
pubmed: 22886508
Hepatology. 2011 May;53(5):1629-40
pubmed: 21520176
Pharmacol Rev. 2012 Jul;64(3):676-705
pubmed: 22722893
Nat Rev Gastroenterol Hepatol. 2017 Aug;14(8):455-466
pubmed: 28634412
Curr Pharm Biotechnol. 2011 Dec;12(12):2108-20
pubmed: 21619534
Hepatology. 2009 Apr;49(4):1245-56
pubmed: 19137587
Hepatology. 2018 Apr;67(4):1270-1283
pubmed: 28940700
J Clin Oncol. 2020 Dec 20;38(36):4317-4345
pubmed: 33197225
Acta Gastroenterol Belg. 2020 Apr-Jun;83(2):301-307
pubmed: 32603050
Hepatology. 2014 Jul;60(1):334-48
pubmed: 24619965