Probiotics Do Not Alter the Long-Term Stability of the Supragingival Microbiota in Healthy Subjects: A Randomized Controlled Trial.
16S rDNA
homeostasis
oral microbiota
probiotics
Journal
Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317
Informations de publication
Date de publication:
24 Mar 2021
24 Mar 2021
Historique:
received:
02
03
2021
revised:
18
03
2021
accepted:
22
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
The purpose of the present study was to longitudinally characterize the supragingival microbiota throughout a three months period in orally healthy individuals. We tested the hypothesis that the supragingival microbiota shows a high degree of compositional stability, which is resilient against the external perturbation of regular use of probiotics, as long as oral health is maintained. The present study was a double-blinded, randomized, placebo-controlled clinical trial. The study population comprised a total of 110 oral and systemic healthy individuals, distributed in a probiotic ( No significant changes of the core microbiota, as expressed by relative abundance of predominant genera and species were evident during the three months observation period in the probiotic or the placebo group. Data from the present study clearly demonstrate long term compositional stability of the supragingival microbiota as long as oral health is maintained. In addition, the tested probiotics had no augmenting effect on the supragingival microbiota in oral health.
Sections du résumé
BACKGROUND
BACKGROUND
The purpose of the present study was to longitudinally characterize the supragingival microbiota throughout a three months period in orally healthy individuals. We tested the hypothesis that the supragingival microbiota shows a high degree of compositional stability, which is resilient against the external perturbation of regular use of probiotics, as long as oral health is maintained.
METHODS
METHODS
The present study was a double-blinded, randomized, placebo-controlled clinical trial. The study population comprised a total of 110 oral and systemic healthy individuals, distributed in a probiotic (
RESULTS
RESULTS
No significant changes of the core microbiota, as expressed by relative abundance of predominant genera and species were evident during the three months observation period in the probiotic or the placebo group.
CONCLUSIONS
CONCLUSIONS
Data from the present study clearly demonstrate long term compositional stability of the supragingival microbiota as long as oral health is maintained. In addition, the tested probiotics had no augmenting effect on the supragingival microbiota in oral health.
Identifiants
pubmed: 33805208
pii: pathogens10040391
doi: 10.3390/pathogens10040391
pmc: PMC8064340
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Danmarks Frie Forskningsfond
ID : n.a.
Organisme : Deerland Probiotics and Enzymes A/S
ID : n.a
Références
Nature. 2012 Jun 13;486(7402):207-14
pubmed: 22699609
Front Med (Lausanne). 2018 May 07;5:124
pubmed: 29868585
J Periodontal Res. 1966;1:1-13
pubmed: 4224181
NPJ Biofilms Microbiomes. 2017 Jan 26;3:2
pubmed: 28649403
J Clin Periodontol. 2017 Mar;44 Suppl 18:S12-S22
pubmed: 28266111
Periodontol 2000. 2020 Feb;82(1):173-185
pubmed: 31850634
Nutrients. 2013 Jul 05;5(7):2530-50
pubmed: 23857225
J Dent Res. 2011 Jun;90(6):704-10
pubmed: 21558542
Sci Rep. 2017 Feb 27;7:43344
pubmed: 28240240
PLoS One. 2013 Aug 14;8(8):e71227
pubmed: 23967169
J Bacteriol. 2001 Jun;183(12):3770-83
pubmed: 11371542
J Oral Microbiol. 2019 Jun 26;11(1):1633194
pubmed: 31275531
Clin Prev Dent. 1982 Jan-Feb;4(1):5-8
pubmed: 6980082
ISME J. 2012 Aug;6(8):1621-4
pubmed: 22402401
Benef Microbes. 2018 Apr 25;9(3):487-494
pubmed: 29264967
Infect Immun. 2008 May;76(5):1889-96
pubmed: 18316382
J Dent. 2016 May;48:16-25
pubmed: 26965080
PLoS One. 2015 May 06;10(5):e0125812
pubmed: 25946126
J Appl Microbiol. 2013 Apr;114(4):1132-46
pubmed: 23240984
J Dent Res. 2011 Mar;90(3):294-303
pubmed: 20924061
PLoS One. 2012;7(6):e39315
pubmed: 22720093
Genome Biol. 2012 Jun 14;13(6):R42
pubmed: 22698087
Bioinformatics. 2010 Oct 1;26(19):2460-1
pubmed: 20709691
Nat Commun. 2018 Feb 14;9(1):681
pubmed: 29445174
J Investig Clin Dent. 2018 Aug;9(3):e12338
pubmed: 29604177
J Oral Microbiol. 2015 Apr 07;7:27429
pubmed: 25854857
BMC Oral Health. 2019 Jul 10;19(1):140
pubmed: 31291932
Med Oral Patol Oral Cir Bucal. 2017 May 1;22(3):e282-e288
pubmed: 28390121
Adv Dent Res. 2018 Feb;29(1):60-65
pubmed: 29355410
J Clin Periodontol. 2016 Jun;43(6):520-30
pubmed: 26970230
mSystems. 2018 Dec 4;3(6):
pubmed: 30534599
Br Dent J. 2016 Nov 18;221(10):657-666
pubmed: 27857087
J Clin Periodontol. 2013 May;40(5):483-92
pubmed: 23489056
Expert Rev Anti Infect Ther. 2016 Jul;14(7):643-55
pubmed: 27224284
Clin Oral Investig. 2014 Jul;18(6):1539-52
pubmed: 24663813
JDR Clin Trans Res. 2018 Jan;3(1):57-64
pubmed: 29662960
J Biotechnol. 2014 Nov 20;190:30-9
pubmed: 24670254
J Oral Microbiol. 2017 Aug 1;9(1):1355207
pubmed: 28839520
Stat Med. 1990 Jul;9(7):811-8
pubmed: 2218183
ISME J. 2012 Jan;6(1):46-56
pubmed: 21716308
Bioinformatics. 2015 Nov 1;31(21):3476-82
pubmed: 26139637
J Periodontol. 2009 Sep;80(9):1421-32
pubmed: 19722792
Genome Biol. 2011 Jun 24;12(6):R60
pubmed: 21702898
Clin Oral Investig. 2015 Jan;19(1):77-83
pubmed: 24638207
J Oral Microbiol. 2020 Jan 7;12(1):1710953
pubmed: 32002131
NPJ Biofilms Microbiomes. 2017 Oct 2;3:23
pubmed: 28979798
Caries Res. 2019;53(5):514-526
pubmed: 30947169
Mol Oral Microbiol. 2012 Feb;27(1):34-44
pubmed: 22230464
Dent Clin North Am. 2010 Jul;54(3):441-54
pubmed: 20630188
J Periodontal Res. 1989 Jan;24(1):75-80
pubmed: 2524573