NMRK2 Gene Is Upregulated in Dilated Cardiomyopathy and Required for Cardiac Function and NAD Levels during Aging.
Aging
/ genetics
Animals
Cardiomegaly
/ genetics
Cardiomyopathy, Dilated
/ genetics
Cytosol
/ metabolism
Disease Models, Animal
Electrocardiography
Gene Expression Regulation
Humans
Intracellular Signaling Peptides and Proteins
/ genetics
Laminin
/ metabolism
Mice, Inbred C57BL
Mice, Knockout
NAD
/ metabolism
Niacinamide
/ genetics
Phosphotransferases (Alcohol Group Acceptor)
/ genetics
Up-Regulation
Ventricular Remodeling
/ genetics
dilated cardiomyopathy
eccentric hypertrophy
muscle integrin binding protein
nicotinamide adenine dinucleotide
nicotinamide riboside kinase 2
pressure overload
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Mar 2021
29 Mar 2021
Historique:
received:
19
01
2021
revised:
09
03
2021
accepted:
25
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
2
6
2021
Statut:
epublish
Résumé
Dilated cardiomyopathy (DCM) is a disease of multifactorial etiologies, the risk of which is increased by male sex and age. There are few therapeutic options for patients with DCM who would benefit from identification of common targetable pathways. We used bioinformatics to identify the
Identifiants
pubmed: 33805532
pii: ijms22073534
doi: 10.3390/ijms22073534
pmc: PMC8036583
pii:
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
Laminin
0
NAD
0U46U6E8UK
Niacinamide
25X51I8RD4
NMRK2 protein, human
EC 2.7.1.-
Phosphotransferases (Alcohol Group Acceptor)
EC 2.7.1.-
Nmrk2 protein, mouse
EC 2.7.1.22
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agence Nationale de la Recherche
ID : #ANR-17-CE17-0015-01
Organisme : Association Française contre les Myopathies
ID : MUSCLE-MINDS # 16282
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