Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development-Review.
Alzheimer Disease
/ drug therapy
Animals
Antineoplastic Agents
/ therapeutic use
Apoptosis
/ drug effects
Cardiomegaly
/ drug therapy
Cardiovascular Agents
/ therapeutic use
Cell Cycle
/ drug effects
Cyclin-Dependent Kinases
/ antagonists & inhibitors
Cyclins
/ genetics
Gene Expression Regulation
Humans
Neoplasms
/ drug therapy
Neuroprotective Agents
/ therapeutic use
Parkinson Disease
/ drug therapy
Protein Kinase Inhibitors
/ therapeutic use
Saccharomyces cerevisiae
/ genetics
Stroke
/ drug therapy
cancer
cell cycle
cyclin-dependent kinase
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 Mar 2021
13 Mar 2021
Historique:
received:
09
02
2021
revised:
07
03
2021
accepted:
09
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
24
4
2021
Statut:
epublish
Résumé
Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle and transcription, as well as communication, metabolism, and apoptosis. The kinases are organized in a pathway to ensure that, during cell division, each cell accurately replicates its DNA, and ensure its segregation equally between the two daughter cells. Deregulation of any of the stages of the cell cycle or transcription leads to apoptosis but, if uncorrected, can result in a series of diseases, such as cancer, neurodegenerative diseases (Alzheimer's or Parkinson's disease), and stroke. This review presents the current state of knowledge about the characteristics of cyclin-dependent kinases as potential pharmacological targets.
Identifiants
pubmed: 33805800
pii: ijms22062935
doi: 10.3390/ijms22062935
pmc: PMC7998717
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Cardiovascular Agents
0
Cyclins
0
Neuroprotective Agents
0
Protein Kinase Inhibitors
0
Cyclin-Dependent Kinases
EC 2.7.11.22
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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