Metabolic Signature of Arrhythmogenic Cardiomyopathy.

ACM asymmetric dimethylarginine (ADMA) biocrates metabolomics nitric oxide (NO)

Journal

Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790

Informations de publication

Date de publication:
25 Mar 2021
Historique:
received: 30 01 2021
revised: 06 03 2021
accepted: 23 03 2021
entrez: 3 4 2021
pubmed: 4 4 2021
medline: 4 4 2021
Statut: epublish

Résumé

Arrhythmogenic cardiomyopathy (ACM) is a genetic-based cardiac disease accompanied by severe ventricular arrhythmias and a progressive substitution of the myocardium with fibro-fatty tissue. ACM is often associated with sudden cardiac death. Due to the reduced penetrance and variable expressivity, the presence of a genetic defect is not conclusive, thus complicating the diagnosis of ACM. Recent studies on human induced pluripotent stem cells-derived cardiomyocytes (hiPSC-CMs) obtained from ACM individuals showed a dysregulated metabolic status, leading to the hypothesis that ACM pathology is characterized by an impairment in the energy metabolism. However, despite efforts having been made for the identification of ACM specific biomarkers, there is still a substantial lack of information regarding the whole metabolomic profile of ACM patients. The aim of the present study was to investigate the metabolic profiles of ACM patients compared to healthy controls (CTRLs). The targeted Biocrates AbsoluteIDQ

Identifiants

pubmed: 33805952
pii: metabo11040195
doi: 10.3390/metabo11040195
pmc: PMC8064316
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Department of Innovation and Research and University of the Autonomous Province of Bolzano/Bozen
ID : xxx

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Auteurs

Chiara Volani (C)

Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100 Bolzano, Italy.

Johannes Rainer (J)

Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100 Bolzano, Italy.

Vinicius Veri Hernandes (VV)

Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100 Bolzano, Italy.

Viviana Meraviglia (V)

Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100 Bolzano, Italy.

Peter Paul Pramstaller (PP)

Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100 Bolzano, Italy.

Sigurður Vidir Smárason (SV)

Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100 Bolzano, Italy.

Giulio Pompilio (G)

Unit of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino IRCCS, Via Parea 4, 20138 Milan, Italy.
Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, 20138 Milan, Italy.

Michela Casella (M)

Heart Rhythm Center, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.
Cardiology and Arrhythmology Clinic, University Hospital Ospedali Riuniti Umberto I-Lancisi-Salesi, 60126 Ancona, Italy.
Department of Clinical, Special and Dental Sciences, Marche Polytechnic University, 60126 Ancona, Italy.

Elena Sommariva (E)

Unit of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino IRCCS, Via Parea 4, 20138 Milan, Italy.

Giuseppe Paglia (G)

School of Medicine and Surgery, Università degli Studi di Milano-Bicocca, 20854 Vedano al Lambro, Italy.

Alessandra Rossini (A)

Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100 Bolzano, Italy.

Classifications MeSH